Severe acute intoxication with yohimbine: Four simultaneous poisoning cases
Severe acute intoxication with yohimbine: Four simultaneous poisoning cases
复制标题
DOI：
10.1016/j.forsciint.2021.110705
复制
发表时间：
2021-01-30
影响因子：
2.2
通讯作者：
Gong, Wenjing
中科院分区：
文献类型：
--
作者：
Zhu, Lei;Han, Xiao;Gong, Wenjing
育亨宾是一种吲哚类生物碱，来自Pausinystalia johimbe树的叶子和树皮，在治疗勃起功能障碍方面获得了令人羡慕的声誉。本报告介绍了4例育亨宾引起的同时严重中毒/死亡病例。检测样本为4名疑似中毒的中年男子（年龄47-65岁）的静脉血，其中1人因抢救无效死亡。采用气相色谱-火焰离子化检测器（GC-FID）和液相色谱-串联质谱（LC-MS/MS）进行乙醇浓度测定和毒理学常规筛选。一个特定的LC-MS/MS方法被开发来定量育亨宾，它显示浓度为459，249和301 ng/mL的三个中毒的血液样本和浓度高达5631 ng/mL的死者。而且，死者的尸检排除了外伤和既往疾病致死的可能，血液中也没有检测出其他常见的有毒成分。因此，育亨宾中毒似乎是最可能的死因。育亨宾作为一种可用于治疗临床疾病的生物碱和保健品添加剂，其危害性应引起社会的广泛关注。(c)2021爱思唯尔有限公司版权所有。
Yohimbine is an indole alkaloid from the leaves and bark of the Pausinystalia johimbe tree that has acquired an enviable reputation in treating erectile dysfunction. This report presents four simultaneous severe poisoning/death cases caused by yohimbine. The test samples comprised the venous blood of four middle-aged men (aged 47-65) who were suspected of poisoning; one of the men died due to ineffective rescue. Ethanol concentration determination and toxicological routine screening were performed using gas chromatography with flame ionization detection (GC-FID) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). A specific LC-MS/MS method was developed to quantify yohimbine, which showed concentrations of 459, 249, and 301 ng/mL in three poisoned blood samples and concentrations as high as 5631 ng/mL in the deceased. Moreover, the deceased's autopsy ruled out death from trauma and previous illness, and no other common toxic components were detected in his blood. Therefore, yohimbine poisoning appears to be the most likely cause of death. As a type of alkaloid that can be employed in the treatment of clinical diseases and additives for supplements, the danger of yohimbine should be of widespread concern in society.(c) 2021 Elsevier B.V. All rights reserved.