Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders.
Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders.
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发表时间：
2002
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通讯作者：
G. Moore;M. Galloway
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文献类型：
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作者：
G. Moore;M. Galloway
磁共振波谱（MRS）的临床能力的最新发展为研究人员提供了相当深入的了解与情感障碍的病理和治疗相关的潜在神经化学改变。本文综述了MRS在情感性精神障碍研究中的临床应用，讨论了MRS中主要的可见神经化学物质，并阐述了MRS方法学的一些基本原则，如脉冲序列和神经化学定量。此外，在情绪障碍及其治疗领域的一些最新的关键发现，包括药理作用和机制。例如，几个独立的研究小组报告了重度抑郁症、双相情感障碍、惊恐障碍或强迫症患者中枢神经系统中胆碱、肌醇、N-乙酰天冬氨酸和γ-氨基丁酸水平的变化。最后，讨论了目前的发展方向和进一步研究的领域。这篇综述将为读者提供一个基本的基础，在情绪障碍的MRS应用和更新的一些目前的研究结果，在这个迅速发展的学科。
Recent developments in the clinical capabilities of magnetic resonance spectroscopy (MRS) have provided researchers with considerable insight into potential neurochemical alterations associated with the pathology and treatment of affective disorders. This review focuses on the clinical application of MRS to the study of affective disorders, discusses the major MRS visible neurochemicals, and addresses some essential principles of MRS methodology, such as pulse sequences and neurochemical quantitation. Additionally, some of the more recent key findings in the area of mood disorders and their treatment are highlighted, including pharmacological effects and mechanisms. For example, several independent groups have reported alterations in levels of choline, myoinositol, N-acetylaspartate, and gamma-aminobutyric acid in the central nervous systems of patients with major depression, bipolar disorder, panic disorder, or obsessive-compulsive disorder. Finally, the current direction of advances and areas of further investigation are discussed. This review will afford the reader a fundamental foundation in the applications of MRS in mood disorders and an update on some of the current findings in this rapidly developing discipline.