Conjunction of Vocal Production and Perception Regulates Expression of the Immediate Early Gene ZENK in a Novel Cortical Region of Songbirds
Conjunction of Vocal Production and Perception Regulates Expression of the Immediate Early Gene ZENK in a Novel Cortical Region of Songbirds
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DOI：
10.1152/jn.00869.2009
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Chang, Daniel
中科院分区：
文献类型：
--
作者：
Bottjer, Sarah W.;Alderete, Tanya L.;Chang, Daniel
Bottjer SW、Alderete TL、Chang D。声音产生和感知的结合调节鸣禽新皮层区域中立即早期基因 (IEG) ZENK 的表达。 J Neurophysiol 103: 1833-1842, 2010。首次发表于 2010 年 1 月 27 日； doi：10.1152/jn.00869.2009。皮质核 LMAN（前巢状皮质外侧大细胞核）提供基底神经节通路的输出，这对于鸣禽发育过程中习得的发声行为是必需的。 LMAN 由两个子区域组成，即核心和周围的外壳，产生平行穿过前脑的独立通路。 LMAN(shell) 通路形成一个循环回路，其中包括皮质区域、尾外侧巢皮质 (dNCL) 的背侧区域，迄今为止未知该区域与习得的发声行为有关。在这里，我们表明发声强烈诱导斑胸草雀 dNCL 中的 IEG 产品 ZENK。在声音学习的听觉-运动整合阶段，唱歌时听到导师的歌曲比听到同种歌曲更能有效地诱导幼鸟 dNCL 的表达。相比之下，听到同种鸣叫对于诱导成年鸟类的表达相对更有效，无论它们是否发出鸣叫。此外，dNCL 中的 ZENK + 神经元包括属于 LMAN（壳）循环回路一部分的投射神经元，并且在听到导师歌曲的歌唱幼鸟中，高比例的 dNCL 投射神经元表达 ZENK。因此，那些积极完善自己的声音模式以模仿导师歌曲的幼鸟，当它们在听到导师的歌曲时唱歌时，dNCL 神经元中的 ZENK 诱导水平较高，而当它们听到新的同种异种时，其水平较低。这种模式表明 dNCL 是一个与声音学习有关的新大脑区域，其功能受到发育调节。
Bottjer SW, Alderete TL, Chang D. Conjunction of vocal production and perception regulates expression of the immediate early gene (IEG) ZENK in a novel cortical region of songbirds. J Neurophysiol 103: 1833-1842, 2010. First published January 27, 2010; doi: 10.1152/jn.00869.2009. The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for acquisition of learned vocal behavior during development in songbirds. LMAN is composed of two subregions, a core and a surrounding shell, that give rise to independent pathways that traverse the forebrain in parallel. The LMAN(shell) pathway forms a recurrent loop that includes a cortical region, the dorsal region of the caudolateral nidopallium (dNCL), hitherto unknown to be involved with learned vocal behavior. Here we show that vocal production strongly induces the IEG product ZENK in dNCL of zebra finches. Hearing tutor song while singing is more effective at inducing expression in dNCL of juvenile birds during the auditory-motor integration stage of vocal learning than is hearing conspecific song. In contrast, hearing conspecific song is relatively more effective at inducing expression in adult birds, regardless of whether they are producing song. Furthermore, ZENK + neurons in dNCL include projection neurons that are part of the LMAN(shell) recurrent loop and a high proportion of dNCL projection neurons express ZENK in singing juvenile birds that hear tutor song. Thus juvenile birds that are actively refining their vocal pattern to imitate a tutor song show high levels of ZENK induction in dNCL neurons when they are singing while hearing the song of their tutor and low levels when they hear a novel conspecific. This pattern indicates that dNCL is a novel brain region involved with vocal learning and that its function is developmentally regulated.