Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study.
Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study.
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发表时间：
2003-03
期刊：
影响因子：
11.2
通讯作者：
J. Farley;Leia M. Smith;K. Darcy;E. Sobel;D. O'connor;B. Henderson;L. Morrison;M. Birrer
中科院分区：
文献类型：
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作者：
J. Farley;Leia M. Smith;K. Darcy;E. Sobel;D. O'connor;B. Henderson;L. Morrison;M. Birrer
细胞周期蛋白E是G（1）-S转换的关键调节因子。细胞周期蛋白E的表达与多种癌症的生存率有关。本研究评估了细胞周期蛋白E在人卵巢癌中的预后相关性。我们对139例接受妇科肿瘤组111号方案治疗的晚期、次优减容上皮性卵巢癌标本中细胞周期蛋白E的免疫组化表达进行了评价。在62例（45%）晚期卵巢癌患者中观察到高细胞周期蛋白E蛋白表达（>或=40%细胞周期蛋白E阳性肿瘤细胞）。细胞周期蛋白E的表达与年龄、种族、分期、分级、细胞类型或残留病变量无关。细胞周期蛋白E高表达与低表达相比，中位生存期较短（29 +/-2 vs 35 +/-3个月），总生存期较差（P < 0.05）。单变量和多变量回归分析显示，高相对于低细胞周期蛋白E与死亡风险增加40-50%相关（风险率，P <或= 0.05）。用荧光原位杂交技术检测20例细胞周期蛋白E基因扩增。10例cyclin E高表达者中有8例cyclin E基因扩增，而10例低表达者中只有1例cyclin E基因扩增（P < 0.006）。cyclin E高表达是晚期卵巢癌患者预后不良的独立因素，且与cyclin E基因扩增有关。
Cyclin E is a key regulator of the G(1)-S transition. Abnormalities in cyclin E expression have been related to survival in a variety of cancers. This study evaluated the prognostic relevance of cyclin E in human ovarian cancer. Immunohistochemical expression of cyclin E was evaluated in 139 advanced, suboptimally debulked epithelial ovarian cancer specimens from patients treated on Gynecologic Oncology Group protocol 111. High cyclin E protein expression (> or =40% cyclin E positive tumor cells) was seen in 62 (45%) of the advanced, suboptimally debulked ovarian cancer patients. Expression of cyclin E was not associated with age, race, stage, grade, cell type, or amount of residual disease. High verses low cyclin E expression was associated with a shorter median survival (29 +/- 2 versus 35 +/- 3 months) and worse overall survival (P < 0.05). Univariate and multivariate regression analyses revealed that high relative to low cyclin E was associated with a 40-50% increase in the risk of death (hazard rate, P < or = 0.05). Fluorescence in situ hybridization was used in a subset of 20 cases to examine cyclin E gene amplification. Eight of 10 cases with high cyclin E expression exhibited amplification of the cyclin E gene, whereas only 1 of 10 cases with low expression displayed gene amplification (P < 0.006). High cyclin E expression was an independent poor prognostic factor for patients with advanced ovarian cancer, and it was associated with amplification of the cyclin E gene.