Emergence of a New Lineage of Dengue Virus Type 2 Identified in Travelers Entering Western Australia from Indonesia, 2010-2012
Emergence of a New Lineage of Dengue Virus Type 2 Identified in Travelers Entering Western Australia from Indonesia, 2010-2012
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DOI：
10.1371/journal.pntd.0003442
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发表时间：
2015-01-01
影响因子：
3.8
通讯作者：
Imrie, Allison
中科院分区：
文献类型：
--
作者：
Ernst, Timo;McCarthy, Suzi;Imrie, Allison
登革热病毒 (DENV) 传播在整个热带地区普遍存在。目前全球70%以上的登革热疾病负担是由居住在亚太地区的人们承担的。我们对 2010 年至 2012 年期间进入西澳大利亚的旅行者（其中大多数访问过印度尼西亚）中分离出的 DENV E 基因进行了测序，并鉴定了多种 DENV1-4，包括多个共循环病毒谱系。大多数病毒与已知在印度尼西亚传播了一段时间的谱系密切相关，这表明该地理区域是登革热遗传多样性的主要中心。最值得注意的是，我们发现了 2011-2012 年在巴厘岛出现的 DENV-2（大都会基因型）的新谱系。应明确监测这一谱系的传播。对有症状的回国旅行者的监测提供了有关流行的登革热病毒血清型和基因型的重要而及时的信息，并可以揭示登革热和其他新出现的传染病的前兆。
Dengue virus (DENV) transmission is ubiquitous throughout the tropics. More than 70% of the current global dengue disease burden is borne by people who live in the Asia-Pacific region. We sequenced the E gene of DENV isolated from travellers entering Western Australia between 2010-2012, most of whom visited Indonesia, and identified a diverse array of DENV1-4, including multiple co-circulating viral lineages. Most viruses were closely related to lineages known to have circulated in Indonesia for some time, indicating that this geographic region serves as a major hub for dengue genetic diversity. Most notably, we identified a new lineage of DENV-2 (Cosmopolitan genotype) that emerged in Bali in 2011-2012. The spread of this lineage should clearly be monitored. Surveillance of symptomatic returned travellers provides important and timely information on circulating DENV serotypes and genotypes, and can reveal the herald wave of dengue and other emerging infectious diseases.