Steroids and osteoporosis: the quest for mechanisms
Steroids and osteoporosis: the quest for mechanisms
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DOI：
10.1172/jci68062
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发表时间：
2013-05-01
影响因子：
15.9
通讯作者：
Manolagas, Stavros C.
中科院分区：
文献类型：
--
作者：
Manolagas, Stavros C.
在过去35年中取得的进展提高了我们对类固醇激素作用于骨的机制以及激素水平的生理、病理或医源性变化如何导致骨折风险增加的理解。雌激素、雄激素和糖皮质激素通过调节破骨细胞和成骨细胞的供应和寿命来改变骨的细胞组成。此外，它们影响骨细胞的存活，骨细胞是埋藏在矿化基质中的长寿细胞，并介导骨对机械力的稳态适应。氧化还原平衡改变是这些影响的一个近端潜在机制，性类固醇缺乏或糖皮质激素过量会导致骨骼老化。
Advances made during the last 35 years have improved our understanding of the mechanisms of steroid hormone action on bone and how physiologic, pathologic, or iatrogenic changes in hormone levels can lead to increased fracture risk. Estrogens, androgens, and glucocorticoids alter the cellular composition of bone by regulating the supply and lifespan of osteoclasts and osteoblasts. Additionally, they influence the survival of osteocytes, long-lived cells that are entombed within the mineralized matrix and mediate the homeostatic adaptation of bone to mechanical forces. Altered redox balance is a proximal underlying mechanism of some of these effects, and sex steroid deficiency or glucocorticoid excess contributes to the aging of the skeleton.