Cognitive Deficits in the Remitted State of Unipolar Depressive Disorder
Cognitive Deficits in the Remitted State of Unipolar Depressive Disorder
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DOI：
10.1037/a0029301
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发表时间：
2012-09-01
期刊：
影响因子：
2.4
通讯作者：
Kessing, Lars Vedel
中科院分区：
文献类型：
--
作者：
Hasselbalch, Bo Jacob;Knorr, Ulla;Kessing, Lars Vedel
背景：单相抑郁障碍患者在缓解期可能出现认知缺陷，本研究的目的是调查是否存在特定认知领域的认知缺陷。方法：通过丹麦登记簿(公民登记簿、丹麦精神病学登记簿)，我们确定了40至80岁在精神病院首次出院时被诊断为单相情感障碍的个体，以及性别和年龄匹配的对照组。特别强调的是确保患者处于缓解状态。认知功能通过广泛的神经心理测试进行评估。结果：共纳入88例患者和50例对照。在对年龄、性别、教育程度、病前智商和残留抑郁症状进行同步调整的多元线性回归分析中，单相情感障碍的诊断预示着在跟踪测试、符号数字模式测试和Stroop测试中表现较差。结论：单相障碍缓解期患者存在认知功能障碍。这些缺陷似乎更多地存在于注意力的认知领域，可能表现为处理速度和认知灵活性的损害。
Background: Patients with unipolar depressive disorder may present with cognitive deficits in the remitted state, and the aim of the present study was to investigate whether cognitive deficits within specific cognitive domains are present. Method: Via the Danish registers (Civil Person Register, Danish Psychiatric Register) we identified individuals between 40 and 80 years of age with a diagnosis of unipolar disorder at their first discharge from a psychiatric hospital, and a gender- and age-matched control group. Particular emphasis was placed on assuring that patients were in a remitted state. Cognitive function was assessed with a broad range of neuropsychological tests. Results: A total of 88 patients and 50 controls were included in the study. In multiple linear regression analyses with simultaneous adjustment for age, gender, education level, premorbid IQ, and residual depressive symptoms, a diagnosis of unipolar disorder predicted lower performance on the Trail Making Test, the Symbol Digit Modalities Test, and on the Stroop test. Conclusion: Cognitive deficits are present in patients with unipolar disorder in the remitted state. The deficits seem to reside more within the cognitive domain of attention than within other domains, and may be characterized by impairment of processing speed and cognitive flexibility.