A family study in Oman: Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases
A family study in Oman: Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases
复制标题
DOI：
10.1159/000083341
复制
发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Bayoumi, RA
中科院分区：
文献类型：
--
作者：
Hassan, MO;Albarwani, S;Bayoumi, RA
目的：为复杂疾病的遗传学研究建立合适的人类模型。研究方法：我们选择了一个阿曼阿拉伯人口提供所需的统计能力，研究复杂疾病的遗传学与信心。该模型由5个多代高度近交的家系组成，这些家系来自几代前的少数创始人，具有环境同质性、有限的地理分布、详细的记录和充分确定和验证的家系。采用严格的标准定义高血压、糖尿病、血脂异常和肥胖的表型。用SOLAR遗传软件包绘制家系结构。结果：获得了显著的统计功效来检测易感位点。结论：该模型代表了一个大型的同质人类家庭为基础的人口的遗传和环境因素的研究，有助于复杂的疾病。版权所有© 2005 S. Karger AG，巴塞尔。
Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-ascertained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstanding statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases. Copyright © 2005 S. Karger AG, Basel.