Electrical stimulation of paraventricular nucleus increases plasma renin activity.
Electrical stimulation of paraventricular nucleus increases plasma renin activity.
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电刺激室旁核可增加血浆肾素活性。
DOI：
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发表时间：
1988
影响因子：
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通讯作者：
James P. Porter
中科院分区：
文献类型：
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作者：
James P. Porter
采用直接电刺激肾神经的研究表明，根据使用的频率，可以诱发对肾功能的选择性影响。在低频率下，肾素分泌增加可引起而不影响肾小球滤过率、钠排泄或肾血流量。在目前的研究中，中枢神经系统（CNS）也被组织起来引起肾功能的选择性改变。在清醒大鼠的下丘脑室旁核（PVN）以150微a和频率为2.5、5、10和15 Hz的电刺激。在每次5min刺激前和结束时采集血样，测定血浆肾素活性（PRA）。较低频率对PRA没有影响，但10和15 Hz的刺激可显著增加PRA。这种对PRA的影响不伴有动脉压或肾血流量的变化。在另一组动物中，以15 Hz刺激PVN可显著减少尿量，但钠排泄量没有变化。这些数据提出了一种可能性，即中枢神经系统被组织为选择性地唤起交感神经流向肾脏的增加，并产生单独的肾功能变化。
Studies employing direct electrical stimulation of the renal nerves have shown that, depending on the frequency used, selective effects on renal function can be evoked. With low frequencies, an increase in renin secretion can be elicited without affecting glomerular filtration rate, sodium excretion, or renal blood flow. In the present investigation the possibility was addressed that the central nervous system (CNS) is also organized to evoke selective changes in renal function. The paraventricular nucleus (PVN) of the hypothalamus was electrically stimulated in conscious rats with 150 microA and frequencies of 2.5, 5, 10, and 15 Hz. Blood samples for determination of plasma renin activity (PRA) were collected before and at the end of each 5-min stimulation period. The lower frequencies had no effect on PRA, but stimulation with 10 and 15 Hz produced a significant increase. This effect on PRA was not accompanied by changes in arterial pressure or renal blood flow. In a separate group of animals, stimulation of the PVN with 15 Hz produced a marked decrease in urine volume, but sodium excretion did not change. These data raise the possibility that the CNS is organized to evoke selective increases in sympathetic outflow to the kidney and to produce separate changes in renal functions.