THE EFFECT OF SODIUM IONS ON THE ELECTRICAL ACTIVITY OF THE GIANT AXON OF THE SQUID
THE EFFECT OF SODIUM IONS ON THE ELECTRICAL ACTIVITY OF THE GIANT AXON OF THE SQUID
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DOI：
10.1113/jphysiol.1949.sp004310
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发表时间：
1949-01-01
影响因子：
5.5
通讯作者：
KATZ, B
中科院分区：
文献类型：
--
作者：
HODGKIN, AL;KATZ, B
用微电极测定神经元的电活动，发现在无钠溶液中，巨轴突的动作电位消失。当海水被替换时返回。用葡萄糖稀释海水，静息电位略有增加，但动作电位的高度出现大幅度可逆性下降。高渗氯化钠使动作电位的高度增加。值得注意的是，这些变化的膜电位与改变外部钠，是相同的数量级的Na电极。在低Na含量的溶液中，导电速度显著降低，用葡萄糖稀释海水所产生的变化与Na含量的变化一致。增加钾引起静息电位和动作电位的降低，而减少钾则引起一定程度的升高。假设活动状态下的渗透性条件与静息状态下的渗透性条件相反，可以解释动作电位期间膜电位的逆转。
The electrical activity was measured by a microelectrode and it was found that the action potential of the giant axon was abolished in Na free solns., returning when sea water was replaced. Dilution of the sea water with dextrose produced a slight increase in resting potential, but a large and reversible decrease in the height of the action potential. The height of the action potential was increased by hypertonic NaCl. It was noted that these changes in membrane potential with alteration of external Na, were of the same order of magnitude as those for the Na electrode. The conduction velocity was substantially decreased in low Na content solns., and the changes produced by diluting sea water with dextrose were found to be consistent with alterations of the Na content. Increase of K caused depression of resting and action potential, whereas decrease caused some increase. The reversal of membrane potential during action potential was explained by assuming that the permeability conditions in the active state are the reverse of those in the resting state.