Case report: Pediatric anti-gamma aminobutyric acid-B receptor encephalitis with benign prognosis.
Case report: Pediatric anti-gamma aminobutyric acid-B receptor encephalitis with benign prognosis.
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DOI：
10.3389/fped.2023.1104001
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发表时间：
2023
影响因子：
2.6
通讯作者：
Gao, Feng
中科院分区：
文献类型：
--
作者：
Wang, Yeping;Ren, Xiaoyan;Shen, Yu;Hua, Yi;Xu, Lu;Zhang, Weiran;Sheng, Guoxia;Jiang, Peifang;Yuan, Zhefeng;Liu, Liu;Gao, Feng
探讨小儿抗-氨基丁酸- b受体（GABABR）脑炎的临床特点，提高对该病的认识，改进该病的诊断和治疗策略。我们报告一例罕见的女性儿童患者抗gababr脑炎谁是在浙江大学医学院儿童医院治疗。通过文献检索，探讨小儿抗gababr脑炎的临床特点。患者在11岁零10个月时表现为反复发作的癫痫发作、癫痫持续状态和精神症状。脑脊液和血清抗gababr抗体阳性。脑磁共振成像（MRI）显示左海马异常信号。在给予免疫抑制剂、抗癫痫和抗精神病药物后，症状和脑MRI异常得到改善。通过文献检索，发现2例有临床资料的小儿抗gababr脑炎。分析这3例患儿，提示患儿以边缘脑炎为主，无肿瘤发生。所有病例均表现出良好的免疫治疗反应和良好的预后。我们报告了一例早期发病的儿童抗gababr脑炎病例。及时进行自身免疫抗体检测和肿瘤筛查，以及在确诊后立即进行免疫调节治疗，以改善预后。
To explore the clinical characteristics of pediatric anti-gamma-aminobutyric acid-B receptor (GABABR) encephalitis to enhance the understanding and improve the diagnostic and therapeutic strategies for this disease. We report a rare case of a female pediatric patient with anti-GABABR encephalitis who was treated at the Children's Hospital of Zhejiang University School of Medicine. Literature search was performed to explore the clinical characteristics of pediatric anti-GABABR encephalitis. The patient exhibited recurrent epileptic seizure, status epilepticus, and psychiatric symptoms at the age of 11 years and 10 months. Anti-GABABR antibodies were positive in cerebrospinal fluid and serum. Brain magnetic resonance imaging (MRI) exhibited abnormal signals in the left hippocampus. Symptoms and abnormality of brain MRI were improved after administration of immunosuppressants, anti-seizure and antipsychotic drugs. Two of pediatric anti-GABABR encephalitis with clinical data were identified through literature search. Analysis of these three cases suggested that the pediatric patients primarily experienced limbic encephalitis, with no tumor incidence. A favorable immunotherapy response was demonstrated with a superior prognosis in all the cases. We reported a pediatric anti-GABABR encephalitis case with early age of onset. Promt autoimmune antibody testing and tumor screening, as well as immunomodulatory treatment immediately after a definitive diagnosis are warranted to improve prognosis.
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影响因子：
9.9
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Hong, Zhen
影响因子：
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作者：
Hoeftberger, Romana;Titulaer, Maarten J.;Graus, Francesc
通讯作者：
Graus, Francesc
影响因子：
29
作者：
Kruer MC;Hoeftberger R;Lim KY;Coryell JC;Svoboda MD;Woltjer RL;Dalmau J
通讯作者：
Dalmau J