Microglia and Astrocytes in Neuro-Aids, Alzheimers Disease, and Multiple Sclerosis.
Microglia and Astrocytes in Neuro-Aids, Alzheimers Disease, and Multiple Sclerosis.
复制标题
DOI：
10.1100/tsw.2001.107
复制
发表时间：
2001
影响因子：
--
通讯作者：
Eisdorfer K
中科院分区：
文献类型：
--
作者：
Minagar A;Shapshak P;Heyes M;Sheremata WA;Fujimara R;Ownby R;Goodkin K;Eisdorfer K
METHODS. Our methods of analysis include quantitative polymerase chain reaction (PCR), and combined in situ hybridization and immunohistochemistry. Epidemiological and ethnographic studies as well as subject clinical evaluation were done. In addition, we have extensively reviewed the literature and will report our synthesis of the review.RESULTS. MØ play destructive roles in HAD, AD, and MS while astrocytes play a protective role only in MS. Astrocytes have a destructive role in HAD and AD.DISCUSSION. The goal of this short report is to assess the data relevant to the balance between microglia and astrocytes stimulation and their role in the interactions between brain and the immune system. Activated macrophage/microglia (MØ) and astrocytes participate in pathogenesis of these three neurological diseases through expressing of MHC and adhesion molecules and releasing reactive oxygen intermediates, quinolinic acid, chemokines, cytokines, and other components of inflammation. There is a balance between the MØ and astrocytes and their effects on Th1/Th2 in the brain. 3, 4 The players are the same in the three diseases, yet the primary causes of each disease are different enough to result in different courses of pathogenesis. We will diagram and specify the protective as well as pathogenic roles of MØ and astrocytes in the three diseases.
