Functional Near-Infrared Spectroscopy Evidence for Development of Prefrontal Engagement in Working Memory in Early Through Middle Childhood
Functional Near-Infrared Spectroscopy Evidence for Development of Prefrontal Engagement in Working Memory in Early Through Middle Childhood
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DOI：
10.1093/cercor/bhv139
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发表时间：
2016-06-01
期刊：
影响因子：
3.7
通讯作者：
Luna, Beatriz
中科院分区：
文献类型：
--
作者：
Perlman, Susan B.;Huppert, Theodore J.;Luna, Beatriz
工作记忆的神经基础被假设为在学龄前和早期学龄期间逐渐发展，与这一时期执行功能的快速成熟相吻合。本研究探讨了3-7岁儿童前额叶皮质功能的发展。68名儿童参与了一项新的空间工作记忆任务，同时用功能近红外光谱(FNIRS)监测了他们的中、外侧前额叶皮质(LPFC)。当比较工作记忆和休息时，我们发现LPFC的激活增加。与较短的延迟时间相比，较长时间的LPFC增加更大。LPFC的激活、准确性和反应速度的增加与儿童年龄呈正相关，提示前额叶功能的发展变化可能是该年龄段执行功能有效发展的基础。
The neural underpinnings of working memory are hypothesized to develop incrementally across preschool and early school age, coinciding with the rapid maturation of executive function occurring during this period. This study investigates the development of prefrontal cortex function between the ages of 3 and 7. Children (n = 68) participated in a novel spatial working memory task while their middle and lateral prefrontal cortex (LPFC) was monitored using functional near infrared spectroscopy (fNIRS). We found increased activation of the LPFC when comparing working memory to rest. Greater LPFC increase was noted for longer compared with shorter delay periods. Increase in LPFC activation, accuracy, and response speed were positively correlated with child age, suggesting that developmental changes in prefrontal function might underlie effective development of executive function in this age range.