Myoepithelial cells: Their origin and function in breast morphogenesis and neoplasia
Myoepithelial cells: Their origin and function in breast morphogenesis and neoplasia
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DOI：
10.1007/s10911-005-9586-4
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Bissell, Mina J.
中科院分区：
文献类型：
--
作者：
Gudjonsson, Thorarinn;Adriance, Melissa C.;Bissell, Mina J.
人类乳腺上皮是一个分支导管系统，由内层极化的管腔上皮细胞和外层的肌上皮细胞组成，肌上皮细胞终止于远端的导管小叶单位(TDLU)。虽然腔上皮细胞作为功能活跃的产奶细胞和最有可能致癌的靶细胞而受到最多的关注，但随着人们对肌上皮细胞在分支、形态发生和肿瘤抑制中发挥积极作用的认识，对肌上皮细胞的关注也开始演变。作为研究主题的一个主要问题涉及腔上皮和肌上皮谱系是如何相关的，以及它们确切地说是如何从乳房内常见的假定干细胞群体中产生的。同样重要的是，在正常的乳腺形态发生和肿瘤形成中，腔上皮和周围肌上皮细胞之间的异型信号是如何发生的。在这篇综述中，我们讨论了来自我们的实验室和其他实验室的数据，关于人类肌上皮细胞的细胞起源，它们在正常乳腺中维持组织极性的功能，以及它们在肿瘤形成中的作用。
The human breast epithelium is a branching ductal system composed of an inner layer of polarized luminal epithelial cells and an outer layer of myoepithelial cells that terminate in distally located terminal duct lobular units (TDLUs). While the luminal epithelial cell has received the most attention as the functionally active milk-producing cell and as the most likely target cell for carcinogenesis, attention on myoepithelial cells has begun to evolve with the recognition that these cells play an active part in branching morphogenesis and tumor suppression. A major question that has been the subject of investigation pertains to how the luminal epithelial and myoepithelial lineages are related and precisely how they arise from a common putative stem cell population within the breast. Equally important is the question of how heterotypic signaling occurs between luminal epithelial and surrounding myoepithelial cells in normal breast morphogenesis and neoplasia. In this review we discuss data from our laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia.