Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells.
Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells.
复制标题
尼群地平、硝苯地平和维拉帕米抑制体外不可逆镰状细胞的形成。
DOI：
10.1159/000138177
复制
发表时间：
1986
期刊：
影响因子：
3.1
通讯作者：
K. Sadanaga
中科院分区：
文献类型：
--
作者：
S. Ohnishi;K. Horiuchi;K. Horiuchi;M. Jurman;K. Sadanaga
尼群地平、硝苯地平和维拉帕米抑制体外不可逆镰状细胞的形成。采用体外培养的方法，通过反复的镰状化和非镰状化循环，同时形成脱水细胞和不可逆镰状细胞，研究了几种药物抑制这些细胞形成的作用。被称为钙通道拮抗剂的药物，如尼群地平，硝苯地平和维拉帕米被发现可以抑制这些反应。其他类型的钙通道阻滞剂，如镧和锌，没有抑制这些细胞的形成。药物抑制不可逆镰状细胞形成的效力与抑制钙调素激活的磷酸二酯酶的效力有关。
Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells. Using a method of forming both dehydrated cells and irreversibly sickled cells in vitro by repeated cycles of sickling and unsickling, the effects of several drugs in inhibiting the formation of these cells were studied. Drugs known as Ca2+ channel antagonists, such as nitrendipine, nifedipine and verapamil were found to inhibit these reactions. Other types of calcium channel blockers, such as lanthanum and zinc, did not inhibit the formation of these cells. The potency of drugs to inhibit irreversibly sickled cell formation was related to the potency of inhibition of calmodulin-activated phosphodiesterase.