Hybrid adiabatic-rectangular pulse train for effective saturation of magnetization within the whole heart at 3 T.

Hybrid adiabatic-rectangular pulse train for effective saturation of magnetization within the whole heart at 3 T.
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DOI:
10.1002/mrm.22140
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发表时间:
2009-12
影响因子:
3.3
通讯作者:
McGorty, KellyAnne
McGorty, KellyAnne
中科院分区:
医学3区
文献类型:
--
作者:
Kim, Daniel;Oesingmann, Niels;McGorty, KellyAnne

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统一的T1加权是3 T下首过心脏灌注MRI的主要挑战。以前提出的绝热B1不敏感旋转(BIR-4)脉冲和标准和定制的脉冲序列的三个非选择性脉冲已经是重要的发展,但每个脉冲在3 T的限制。作为定制脉冲序列的扩展,我们通过协同组合两个非选择性矩形RF脉冲和绝热半通脉冲开发了混合脉冲序列,以实现心脏内磁化的有效饱和,同时保持在临床可接受的比吸收率(SAR)限值内。通过数值、体模和体内实验对标准脉冲序列、定制脉冲序列、混合脉冲序列和BIR-4脉冲序列进行了评价。在四个饱和脉冲中,只有混合脉冲序列产生的剩余磁化强度<心脏中平衡磁化强度的2%,同时保持在3 T下多切片首过心脏灌注MRI的临床可接受SAR限值内。
Uniform T1-weighting is a major challenge for first-pass cardiac perfusion MRI at 3T. Previously proposed adiabatic B1-insensitive rotation (BIR-4) pulse and standard and tailored pulse trains of three non-selective pulses have been important developments but each pulse has limitations at 3T. As an extension of the tailored pulse train, we developed a hybrid pulse train by synergistically combining two non-selective rectangular RF pulses and an adiabatic half-passage pulse, in order to achieve effective saturation of magnetization within the heart, while remaining within clinically acceptable specific absorption rate (SAR) limits. The standard pulse train, tailored pulse train, hybrid pulse train, and BIR-4 pulse train were evaluated through numerical, phantom, and in vivo experiments. Among the four saturation pulses, only the hybrid pulse train yielded residual magnetization < 2% of equilibrium magnetization in the heart, while remaining within clinically acceptable SAR limits for multi-slice first-pass cardiac perfusion MRI at 3T.
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