Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents.
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents.
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DOI：
10.1038/ncomms14140
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发表时间：
2017-02-21
影响因子：
16.6
通讯作者：
IMAGEN consortium
中科院分区：
文献类型：
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作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
青少年追求新奇的倾向可能会促进创新以及有问题的冲动行为，包括药物滥用。以前的研究还没有澄清神经对预期奖励的过度反应或低反应是否会促进这些个体的脆弱性。在这里，我们使用纵向设计跟踪144新奇寻求青少年在14岁和16岁，以确定是否神经活动的预期回报预测有问题的药物使用。我们发现，减少BOLD活动中脑边缘（腹侧纹状体和中脑）和前额叶皮层（背外侧前额叶皮层）地区在奖励预期在14岁预测问题药物使用在16岁。14岁时较低的心理测量学的敏感性和对未来奖励的更大折扣也预测了16岁时有问题的药物使用，但神经反应独立地预测了比心理测量学更大的方差。总之，这些研究结果表明，寻求新奇的青少年对预期奖励的神经反应减弱，可能会增加对未来有问题的药物使用的脆弱性。一些青少年寻求新奇，但这种行为背后的大脑回路是否可以用来预测后来的问题行为，这是未知的。在这里，作者表明，这些人在14岁时对预期奖励做出反应时腹侧纹状体和前额叶活动的减少预示着16岁时有问题的药物使用。
Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use. Some adolescents seek novelty, but it is unknown whether the brain circuits underlying this behaviour can be used to predict later, problematic behaviour. Here, authors show that diminished ventral striatal and prefrontal activity in response to anticipated rewards at age 14 in these individuals predicts problematic drug use at age 16.