Co-infection with Ascaris lumbricoides modulates protective immune responses against Giardia duodenalis in school Venezuelan rural children
Co-infection with Ascaris lumbricoides modulates protective immune responses against Giardia duodenalis in school Venezuelan rural children
复制标题
DOI：
10.1016/j.actatropica.2010.12.001
复制
发表时间：
2011-03-01
期刊：
影响因子：
2.7
通讯作者：
Di Prisco, M. C.
中科院分区：
文献类型：
--
作者：
Hagel, I.;Cabrera, M.;Di Prisco, M. C.
我们评价了251名农村寄生虫和70名城市非寄生虫感染的儿童蛔虫对贾第鞭毛虫感染的影响和对这种寄生虫的TH 1/TH 2型免疫机制。根据轻度（0-5000个卵/g粪便）或中度（> 5001- 50，000个卵/g粪便）将儿童分类。蛔虫感染抗G.尿道皮肤高反应性比较了不同年龄、不同性别、不同年龄、不同性别、不同性别、不同年龄、不同性别、不同性别、不同年龄、不同性别、不同年龄、不同性别、不同性别、不同年龄、不同性别、不同年龄、不同性别、不同性别感染和未感染的儿童按轻度或中度A.蛔虫感染结果表明，62%的A.蛔虫中度感染儿童与蛔虫合并感染。相比之下，轻度感染组的感染率为45%。治疗后，A.中度蛔虫组感染G.与11%的轻度对应物相比，A.在中度感染组中，蛔虫IL-10水平较高（p < 0.0001）。明天早上蛔虫轻度寄生的儿童，G.尿道感染与G.尿道炎IL-13、IFN-γ、IL-6、IgE、IgG和皮试高反应性。而G.在A.蛔虫中度寄生组，这些水平与对照组中观察到的水平类似地较低。抗G抗体、皮试高反应性和细胞因子水平与A.蛔虫感染（p > 0.0001）和A.蛔虫IL-10水平（p > 0.0001），提示联合感染蛔虫可显著降低IL-10水平（p > 0.0001）。蛔虫感染可能同时影响抗蛔虫的TH 1和TH 2型免疫。结论：血吸虫病流行区儿童化疗后易感染血吸虫病，血吸虫感染可能与血吸虫病流行区儿童化疗后易感染有关。(C)2010爱思唯尔有限公司版权所有。
We evaluated the effect of Ascaris lumbricoides on Giardia duodenalis infection and TH1/TH2 type immune mechanisms toward this parasite in 251 rural parasitized and 70 urban non-parasitized school children. The children were classified according to light (0-5000 eggs/g faeces) or moderate (> 5001-50,000 eggs/g faeces) A. lumbricoides infection. Anti G. duodenalis skin hyper-reactivity. IgE, IgG, IL-13, IFN gamma, IL6 and IL-10 levels were compared among G. duodenalis infected and non-infected children according to light or moderate A. lumbricoides infection. It was found that 62% of the A. lumbricoides moderately infected children were co-infected by G. duodenalis compared to 45% of the lightly infected group. After treatment, 42% of the A. lumbricoides moderately group were infected with G. duodenalis compared to 11% of their lightly counterparts, being A. lumbricoides IL-10 levels higher (p < 0.0001) in the moderately infected group. In the A. lumbricoides lightly parasitized children, G. duodenalis infection was associated to a significant increase (p < 0.005) of the levels of G. duodenalis IL-13, IFN-gamma, IL-6, IgE, IgG and skin test hyper reactivity. In contrast, there was no effect of G. duodenalis infection in the elevation of these parameters among the A. lumbricoides moderately parasitized group, being those levels similarly lower as those observed in the control group. Inverse correlations were found between the levels of anti G duodenalis antibodies, skin test hyper-reactivity and cytokines with the intensity of A. lumbricoides infection (p > 0.0001) and A. lumbricoides IL-10 levels (p > 0.0001), suggesting that co-infection with A. lumbricoides may affect both TH1 and TH2 type immunity against G. duodenalis that may play an important role in the susceptibility to the infection after chemotherapy in children from endemic areas. (C) 2010 Elsevier B.V. All rights reserved.