Nutrient intakes and adenocarcinoma of the esophagus and distal stomach
Nutrient intakes and adenocarcinoma of the esophagus and distal stomach
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DOI：
10.1207/s15327914nc421_5
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发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Ward, MH
中科院分区：
文献类型：
--
作者：
Chen, HL;Tucker, KL;Ward, MH
我们在内布拉斯加州东部进行了一项基于人群的病例对照研究，研究了124例食管腺癌病例、124例远端胃癌病例和449例对照者中营养素摄入与食管和远端胃癌的关系。残差法用于调整能量摄入的营养素摄入四分位数或三分位数。我们观察到饮食中总维生素A摄入量[最高与最低四分位数，多变量比值比（OR）= 0.5，趋势P = 0.05]、β-隐黄素（OR = 0.5，P = 0.05），核黄素（OR = 0.5，P = 0.01），叶酸（OR = 0.5，P = 0.03），锌（OR = 0.5，P = 0.05）、膳食纤维（OR = 0.5，P = 0.05）、蛋白质（OR = 0.5，P = 0.02）和碳水化合物（OR = 0.4，P = 0.02）。对于远端胃癌，只有维生素C（OR = 0.6，P = 0.04），膳食纤维（OR = 0.4，P = 0.007）和碳水化合物（OR = 0.4，P = 0.004）与风险呈负相关。我们的分析表明，膳食脂肪摄入量（而不是其他营养素的摄入量）与两个癌症部位的应答类型之间存在显著的相互作用。对自我调查者进行的亚组分析显示，饱和脂肪摄入量与食道腺癌风险（摄入量三分位数的OR = 1.0、4.1和4.6，趋势P = 0.02）和远端胃癌风险（OR = 1.0、1.2和3.6，P = 0.03）之间存在正相关性。然而，在代理受访者中没有发现这种关联。我们的数据表明，摄入更多的膳食纤维，某些类胡萝卜素和维生素可能会降低食管腺癌的风险，而摄入更多的饱和脂肪可能会增加食管腺癌和远端胃癌的风险。
We studied the relationship between nutrient intakes and adenocarcinoma of the esophagus and distal stomach among 124 esophageal adenocarcinoma cases, 124 distal stomach cancer cases, and 449 controls in a population-based case-control study in eastern Nebraska. The residual method was used to adjust nutrient intake quartiles or tertiles for energy intake. We observed significant inverse associations with risk of esophageal adenocarcinoma for dietary intakes of total vitamin A [highest vs. lowest quartile, multi-variate odds ratio (OR) = 0.5, P for trend = 0.05], beta-cryptoxanthin (OR = 0.5, P = 0.05), riboflavin (OR = 0.5, P = 0.01), folate (OR = 0.5, P = 0.03), zinc (OR = 0.5, P = 0.05), dietary fiber (OR = 0.5, P = 0.05), protein (OR = 0.5, P = 0.02), and carbohydrate (OR = 0.4, P = 0.02). For distal stomach cancer, only vitamin C (OR = 0.6, P = 0.04), dietary fiber (OR = 0.4, P = 0.007), and carbohydrate (OR = 0.4, P = 0.004) were inversely associated with risk. Our analyses shoved significant interaction between dietary fat intake, but not intakes of other nutrients, and respondent type for both cancer sites. Subgroup analyses among self-respondents revealed positive associations between saturated fat intake and risk of esophageal adenocarcinoma (OR = 1.0, 4.1, and 4.6 for intake tertiles, P for trend = 0.02) and risk of distal stomach cancer (OR = 1.0, 1.2, and 3.6, P = 0.03). However, no such associations were found among proxy respondents. Our data suggest that greater intake of dietary fiber, certain carotenoids, and vitamins may decrease the risk of esophageal adenocarcinoma, whereas greater intake of saturated fat may increase the risk of esophageal adenocarcinoma and distal stomach cancer.