Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas.
Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas.
复制标题
结直肠癌危险因素与锯齿状息肉和传统腺瘤风险之间的关联。
DOI：
10.1053/j.gastro.2018.04.019
复制
发表时间：
2018-08
期刊：
影响因子：
29.4
通讯作者：
Song M
中科院分区：
文献类型：
--
作者：
He X;Wu K;Ogino S;Giovannucci EL;Chan AT;Song M
锯齿状息肉（SP）和传统腺瘤是结直肠癌（CRC）的前驱病变，但据信是通过不同的途径产生的。我们在对3项大型前瞻性研究的数据进行事后分析后，对SP和传统腺瘤的危险因素进行了特征分析。我们收集了来自护士健康研究（NHS）、NHS 2和健康专业人员随访研究（HPFS）的数据，这些研究对象是发生SP或常规腺瘤的受试者。我们的分析包括141，143名接受过下消化道内窥镜检查的参与者，每2-4年提供更新的饮食和生活方式数据，并进行随访，直到诊断出第一个息肉。我们评估了13个结直肠癌的危险因素在SP或传统腺瘤患者，并检查根据组织病理学特征的协会。在18-20年的随访中，我们记录了7945例SP，9212例常规腺瘤，2382例同步SP和常规腺瘤。吸烟、体重指数、酒精摄入、CRC家族史和身高与SP和常规腺瘤的高风险相关，而维生素D和海洋omega-3脂肪酸的摄入量较高与风险较低相关。同步性SP和传统腺瘤的相关性往往更强。吸烟、体重指数和酒精摄入与SP的相关性比传统腺瘤更强（异质性P <0.05），而体力活动和总叶酸和钙的摄入与传统腺瘤呈负相关，但与SP无关。对于SP和传统腺瘤来说，对于远端结肠和直肠中大于10 mm或具有高级组织学的息肉，这种关联往往更强。在对3项大型前瞻性研究的数据分析中，我们发现尽管SP和传统腺瘤有许多共同的风险因素，但某些因素与一种病变的相关性更强。这些发现为结直肠肿瘤的病因异质性提供了支持。结直肠癌风险因素和锯齿状息肉和传统腺瘤的风险 * 吸烟：目前吸烟者≥30包-年vs从不吸烟者;体重指数：≥35 vs <25 kg/m2;酒精摄入量：男性≥14 g/d vs从不，女性≥7 g/d vs从不;体力活动：≥60 vs <7.5代谢当量任务-小时/周vs;饮食因素：最高四分位数与最低四分位数。
Serrated polyps (SPs) and conventional adenomas are precursor lesions for colorectal cancer (CRC) but believed to arise via distinct pathways. We characterized risk factor profiles for SPs and conventional adenomas in a post-hoc analysis of data from 3 large prospective studies. We collected data from the Nurses’ Health Study (NHS), the NHS2, and the Health Professionals Follow-up Study (HPFS) on subjects who developed SPs or conventional adenomas. Our analysis comprised 141,143 participants who had undergone lower gastrointestinal endoscopy, provided updated diet and lifestyle data every 2–4 years, and were followed until diagnosis of a first polyp. We assessed 13 risk factors for CRC in patients with SPs or conventional adenomas, and examined the associations according to histopathology features. We documented 7945 SPs, 9212 conventional adenomas, and 2382 synchronous SPs and conventional adenomas during 18–20 years of follow up. Smoking, body mass index, alcohol intake, family history of CRC, and height were associated with higher risk of SPs and conventional adenomas, whereas higher intake of vitamin D and marine omega-3 fatty acid were associated with lower risk. The associations tended to be stronger for synchronous SPs and conventional adenomas. Smoking, body mass index, and alcohol intake were more strongly associated with SPs than conventional adenomas (P for heterogeneity <.05), whereas physical activity and intake of total folate and calcium were inversely associated with conventional adenomas but not SPs. For SPs and conventional adenomas, the associations tended to be stronger for polyps in the distal colon and rectum, larger than 10 mm, or with advanced histology. In an analysis of data from 3 large prospective studies, we found that although SPs and conventional adenomas share many risk factors, some factors are more strongly associated with 1 type of lesion than the other. These findings provide support for the etiologic heterogeneity of colorectal neoplasia. Colorectal cancer risk factors and risk of serrated polyp and conventional adenoma *Smoking : current smokers with ≥30 pack-years versus never smokers; Body mass index: ≥35 versus <25 kg/m2; Alcohol intake: ≥14 g/d versus never for men, ≥7 g/d versus never for women; Physical activity: ≥60 versus <7.5 metabolic equivalent task-hours/week versus; Dietary factors: highest quartile versus lowest quartile.
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DOI：
10.1038/ajg.2016.589
发表时间：
2017-03
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Drew DA;Nishihara R;Lochhead P;Kuchiba A;Qian ZR;Mima K;Nosho K;Wu K;Wang M;Giovannucci E;Fuchs CS;Chan AT;Ogino S
通讯作者：
Ogino S
DOI：
10.1136/bmj.d6617
发表时间：
2011-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Aune D;Chan DS;Lau R;Vieira R;Greenwood DC;Kampman E;Norat T
通讯作者：
Norat T
影响因子：
24.5
作者：
Holme, Oyvind;Bretthauer, Michael;Hoff, Geir
通讯作者：
Hoff, Geir
DOI：
10.1158/1940-6207.capr-12-0292
发表时间：
2012-10
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Ahearn TU;Shaukat A;Flanders WD;Rutherford RE;Bostick RM
通讯作者：
Bostick RM
影响因子：
29.4
作者：
Chan AT;Giovannucci EL
通讯作者：
Giovannucci EL