ENDEMIC GOITER IN GILGIT AGENCY, WEST PAKISTAN - WITH AN APPENDIX ON DERMATOGLYPHICS AND TASTE-TESTING
ENDEMIC GOITER IN GILGIT AGENCY, WEST PAKISTAN - WITH AN APPENDIX ON DERMATOGLYPHICS AND TASTE-TESTING
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DOI：
10.1098/rstb.1972.0007
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发表时间：
1972-01-01
影响因子：
6.3
通讯作者：
GRANT, IS
中科院分区：
文献类型：
--
作者：
CHAPMAN, JA;MAHMUD, K;GRANT, IS
对生活在喀喇昆仑喜马拉雅山一个大村庄的碘缺乏人群进行了一项研究。根据McCarrison的研究结果，有证据表明，甲状腺肿的发病率向村庄的最低部分增加，McCarrison在20世纪早期曾在同一地区工作。McCarrison将甲状腺肿发病率的变化归因于下游饮用水污染的增加，并假设细菌性甲状腺肿因素。然而，这里报告的观察结果表明，甲状腺肿发病率与饮用水中的细菌浓度之间没有相关性，水中也没有碘代谢微生物。可能是整个村庄的碘缺乏差异可以解释甲状腺肿发病率的变化，因为土壤可以吸收相当数量的放射性碘。甲状腺功能指数显示，所有居民都异常缺碘，尽管他们中的大多数人临床上甲状腺功能正常。除了平均甲状腺碘清除率大大提高外，该人群的平均肾碘清除率低于正常水平。碘油肌肉注射为村民所接受，共注射477次。指纹和掌纹是从一个样本的人口，产生一个模式分布与其他人口在印度次大陆。居民中PTC品尝者与非品尝者的比例与欧洲的比例没有显着差异。
A study has been made of an iodine-deficient population living in an extended village in the Karakoram Himalayas. There is evidence that the incidence of goitre increases towards the lowest part of the village, in accordance with the findings of McCarrison, who worked in the same region in the early years of the twentieth century. McCarrison ascribed the variation of goitre incidence to increasing pollution of drinking water as it travelled downstream, and postulated a bacteriological goitrogenic factor. However, the observations reported here show no correlation between goitre incidence and the bacterial concentration of drinking water, nor are there iodine-metabolizing micro-organisms present in the water. It may be that a differential iodine deficiency throughout the village can account for the variation in goitre incidence, since the soil can adsorb appreciable amounts of radio-iodine. The indices of thyroid function show that all the inhabitants are exceptionally iodine-deficient, although most of them are clinically euthyroid. As well as having a greatly enhanced mean thyroid iodide clearance the population has a mean renal iodide clearance which is lower than normal. Intra-muscular injections of iodized oil were acceptable to the villagers, and 477 injections were administered. Fingerprints and palm prints were collected from a sample of the population, yielding a pattern distribution comparable with other populations in the Indian subcontinent. The ratio of PTC tasters to non-tasters among the inhabitants is not significantly different from the ratio found in Europe.