Autoimmune Diseases in Women With Turner's Syndrome
Autoimmune Diseases in Women With Turner's Syndrome
复制标题
DOI：
10.1002/art.27270
复制
发表时间：
2010-03-01
影响因子：
--
通讯作者：
Frisch, Morten
中科院分区：
文献类型：
--
作者：
Jorgensen, Kristian T.;Rostgaard, Klaus;Frisch, Morten
客观的。就 X 染色体数量而言，患有特纳综合征的女性在细胞遗传学上与男性相似。在患有特纳综合症的女性中观察到自身免疫性疾病的风险增加。本研究旨在调查患有特纳综合征的女性的自身免疫性疾病特征是否以女性或男性为主的疾病为特征。方法。利用丹麦细胞遗传学中央登记册、丹麦国家患者登记册和丹麦民事登记系统，我们估计了 798 名患有特纳氏综合征的丹麦妇女的 46 种不同自身免疫性疾病的相对风险，该队列在 1980 年至 2004 年间对 12,461 人进行了随访。首次因自身免疫性疾病住院的标准化发病率 (SIR) 和 95% 置信区间 (95% CI) 被用作相对风险的衡量标准。结果。患有特纳综合征的女性患自身免疫性疾病的总体风险是一般丹麦女性的两倍（SIR 2.1 [95% CI 1.6-2.7]）。对于以女性为主的自身免疫性疾病，特纳综合征女性患者的 SIR 为 1.7 (95% CI 1.2-2.4)，而以男性为主的自身免疫性疾病女性的 SIR 为 3.9 (95% CI 2.5-5.8)。桥本甲状腺炎 (SIR 14.6 [95% CI 6.7-27.1])（一种女性占主导地位的疾病）和 1 型糖尿病 (SIR 4.1 [95% CI 2.5-6.3]) 的相关性最强。结论。患有特纳综合征的女性患自身免疫性疾病的风险极高，尤其是以男性为主的自身免疫性疾病。
Objective. In terms of number of X chromosomes, women with Turner's syndrome cytogenetically resemble men. An increased risk of autoimmune diseases has been observed among women with Turner's syndrome. This study was undertaken to investigate whether the autoimmune disease profile in women with Turner's syndrome is characterized by diseases with a female or male predominance.Methods. Using the Danish Cytogenetic Central Register, the Danish National Patient Register, and the Danish Civil Registration System, we estimated relative risk of 46 different autoimmune diseases in a cohort of 798 Danish women with Turner's syndrome followed up for 12,461 person-years between 1980 and 2004. Standardized incidence ratios (SIRs) of first hospitalization for autoimmune disease and 95% confidence intervals (95% CIs) were used as measures of relative risk.Results. The overall risk of autoimmune disease among women with Turner's syndrome was twice that among Danish women in general (SIR 2.1 [95% CI 1.6-2.7]). For autoimmune diseases with a female predominance, the SIR among women with Turner's syndrome was 1.7 (95% CI 1.2-2.4), whereas the SIR for autoimmune diseases with a male predominance among these women was 3.9 (95% CI 2.5-5.8). Associations were strongest for Hashimoto thyroiditis (SIR 14.6 [95% CI 6.7-27.1]), a strongly female-predominant condition, and type 1 diabetes mellitus (SIR 4.1 [95% CI 2.5-6.3]).Conclusion. Women with Turner's syndrome are at excess risk of autoimmune diseases, notably autoimmune diseases characterized by male predominance.