Induction of liver tumors in F344 rats by crotonaldehyde.
Induction of liver tumors in F344 rats by crotonaldehyde.
复制标题
DOI：
--
复制
发表时间：
1986-03
期刊：
影响因子：
11.2
通讯作者：
F. Chung;F. Chung;Takuji Tanaka;S. Hecht
中科院分区：
文献类型：
--
作者：
F. Chung;F. Chung;Takuji Tanaka;S. Hecht
比较了巴豆醛（一种代表性的α，β-不饱和羰基化合物）和N-亚硝基吡咯烷（代谢后可产生巴豆醛）在F344大鼠中的致瘤活性。各组大鼠分别用巴豆醛（0.6 mM或6.0 mM）或N-亚硝基吡咯烷（0.6 mM）在其饮用水中处理113或84周。在0.6 mM剂量下，巴豆醛在27只大鼠中的9只中诱导肝脏肿瘤病变; 2只大鼠患有肝细胞癌，9只大鼠患有肿瘤结节。它还导致27只大鼠中的23只肝细胞灶改变。肿瘤和病灶的发生率明显高于对照组。N-亚硝基吡咯烷诱导23只大鼠中的20只发生肝细胞癌，23只大鼠中的16只发生肝肿瘤结节，23只大鼠中的23只发生肝细胞灶改变。因此，巴豆醛似乎是比N-亚硝基吡咯烷更弱的致瘤剂。在6.0 mM剂量下，巴豆醛处理在23只大鼠中的10只中引起中度至重度肝损伤。在这些大鼠中未观察到癌前病变或肿瘤病变。该组其余13只大鼠出现肝细胞灶改变。巴豆醛的致瘤性表明，α，β-不饱和羰基化合物，这是普遍存在于人类环境中，可以形成内源性，可能是一类重要的潜在致癌物。
The tumorigenic activities in F344 rats of crotonaldehyde, a representative alpha, beta-unsaturated carbonyl compound, and N-nitrosopyrrolidine, which could produce crotonaldehyde upon metabolism, were compared. Groups of rats were treated with either crotonaldehyde (0.6 mM or 6.0 mM) or N-nitrosopyrrolidine (0.6 mM) in their drinking water for 113 or 84 weeks, respectively. At the 0.6 mM dose, crotonaldehyde induced neoplastic lesions of the liver in 9 of 27 rats; 2 rats had hepatocellular carcinomas, and 9 rats had neoplastic nodules. It also caused altered liver cell foci in 23 of 27 rats. The incidences of tumors and foci were significantly higher than those of the control group. N-Nitrosopyrrolidine induced hepatocellular carcinomas in 20 of 23 rats, liver neoplastic nodules in 16 of 23 rats, and altered liver cell foci in 23 of 23 rats. Thus, crotonaldehyde appears to be a weaker tumorigen than N-nitrosopyrrolidine. At the 6.0 mM dose, crotonaldehyde treatment caused moderate to severe liver damage in 10 of 23 rats. No preneoplastic or neoplastic lesions were observed in these rats. The remaining 13 rats of this group developed altered liver cell foci. The tumorigenicity of crotonaldehyde suggests that alpha, beta-unsaturated carbonyl compounds, which are ubiquitous in the human environment and can be formed endogenously, may be an important class of potential carcinogens.