Beneficial Effects of L- and N-type Calcium Channel Blocker on Glucose and Lipid Metabolism and Renal Function in Patients with Hypertension and Type II Diabetes Mellitus
Beneficial Effects of L- and N-type Calcium Channel Blocker on Glucose and Lipid Metabolism and Renal Function in Patients with Hypertension and Type II Diabetes Mellitus
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DOI：
10.1111/j.1755-5922.2009.00126.x
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Izumi, Tohru
中科院分区：
文献类型：
--
作者：
Masuda, Takashi;Ogura, Misao N.;Izumi, Tohru
在糖脂代谢方面，西尼地平组非糖尿病组的胰岛素抵抗（HOMA-R）水平和糖尿病组的甘油三酯水平均显著低于西尼地平组。在糖尿病组的肾功能方面，西尼地平组的肾小球滤过率（eGFR）估计值显著高于西尼地平组，尿白蛋白/肌酐比值显著低于西尼地平组。西尼地平抑制N型钙通道，对高血压和糖尿病患者的糖脂代谢和肾功能的影响更有用。
As for glucose and lipid metabolism, homeostasis model assessment insulin resistance (HOMA-R) level in the non-diabetic group and triglyceride in the diabetes group were significantly lower with cilnidipine than with amlodipine. As regards renal function in the diabetic group, estimated glomerular filtration rate (eGFR) was significantly higher and urinary albumin/creatinine ratio was significantly lower with cilnidipine than with amlodipine.Cilnidipine which inhibits N-type calcium channels is more useful for patients with hypertension and diabetes mellitus from its effects on glucose and lipid metabolism and renal function.