Aging in COVID-19: Vulnerability, immunity and intervention.
Aging in COVID-19: Vulnerability, immunity and intervention.
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DOI：
10.1016/j.arr.2020.101205
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发表时间：
2021-01
影响因子：
13.1
通讯作者：
Leng SX
中科院分区：
文献类型：
--
作者：
Chen Y;Klein SL;Garibaldi BT;Li H;Wu C;Osevala NM;Li T;Margolick JB;Pawelec G;Leng SX
2019年12月，严重急性呼吸综合征冠状病毒-2 （SARS-CoV-2）大流行首次在中国武汉报告，并以前所未有的速度在全球蔓延，对健康和社会经济产生了深远而仍在显现的影响。SARS-CoV-2是一种β冠状病毒，是一种高度传染性的呼吸道病原体，会导致一种被称为2019冠状病毒病（COVID-19）的疾病。迄今为止的临床经验表明，COVID-19具有高度异质性，从无症状和轻度到严重并导致死亡。宿主因素包括年龄、性别和合并症是疾病严重程度和进展的关键决定因素。衰老本身是COVID-19导致严重疾病和死亡的一个重要风险因素。我们假设，与年龄相关的免疫功能下降和失调，即免疫衰老和炎症，是导致老年人更易患COVID-19严重后果的主要原因。关于对SARS-CoV-2感染的免疫反应，还有很多有待了解的地方。我们需要开始按年龄划分所有免疫结果数据，以更好地了解疾病异质性和衰老。这些知识不仅对了解COVID-19的发病机制至关重要，而且对COVID-19疫苗的开发也至关重要。
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first reported in Wuhan, China in December 2019, moved across the globe at an unprecedented speed, and is having a profound and yet still unfolding health and socioeconomic impacts. SARS-CoV-2, a β-coronavirus, is a highly contagious respiratory pathogen that causes a disease that has been termed the 2019 coronavirus disease (COVID-19). Clinical experience thus far indicates that COVID-19 is highly heterogeneous, ranging from being asymptomatic and mild to severe and causing death. Host factors including age, sex, and comorbid conditions are key determinants of disease severity and progression. Aging itself is a prominent risk factor for severe disease and death from COVID-19. We hypothesize that age-related decline and dysregulation of immune function, i.e., immunosenescence and inflammaging play a major role in contributing to heightened vulnerability to severe COVID-19 outcomes in older adults. Much remains to be learned about the immune responses to SARS-CoV-2 infection. We need to begin partitioning all immunological outcome data by age to better understand disease heterogeneity and aging. Such knowledge is critical not only for understanding of COVID-19 pathogenesis but also for COVID-19 vaccine development.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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