Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
复制标题
DOI：
10.1016/j.psychresns.2004.08.002
复制
发表时间：
2004-12-15
影响因子：
2.3
通讯作者：
Soares, JC
中科院分区：
文献类型：
--
作者：
Caetano, SC;Hatch, JP;Soares, JC
MRI形态学研究表明，目前抑郁症患者海马体积减少。对杏仁核的研究结果相互矛盾我们研究了这些颞叶结构和上级颞回（STG）在当前和缓解的抑郁症患者。我们在1.5特斯拉GE Signa成像系统中扫描了31名未经药物治疗的抑郁症患者（21名目前抑郁，10名缓解）和31名匹配的健康对照者。与健康对照组相比，所有抑郁症患者的左侧杏仁核体积都有缩小的趋势。我们发现目前抑郁症患者的双侧海马体积明显小于缓解患者。此外。我们发现在疾病的长度与左侧海马体积和右侧上级颞回体积之间存在统计学上显著的负相关。我们的研究发现，目前抑郁症患者的海马较小，这与皮质醇增多可能导致重度抑郁症海马神经毒性的假设是一致的。较小的海马大小可能更具有抑郁状态的特征，而在缓解患者中不存在。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Morphometric MRI studies suggest decreased hippocampal volumes in currently depressed patients. with conflicting findings for the amygdala. We studied these temporal lobe structures and superior temporal gyrus (STG) in patients with current and remitted major depression. We scanned 31 unmedicated depressed patients (21 currently depressed, 10 remitted) and 31 matched healthy controls with a 3D SPGR sequence in a 1.5 Tesla GE Signa Imaging System. There was a trend towards smaller left amygdala volumes in all depressed patients compared with healthy controls. We found significantly smaller hippocampal volumes bilaterally in currently depressed patients than in remitted patients. Furthermore. we found a statistically significant inverse correlation between length of illness and left hippocampus volumes and fight superior temporal gyrus volumes. Our finding of smaller hippocampi in currently depressed patients is consistent with the hypothesis that hypercortisolism could result in hippocampal neurotoxicity in major depression. A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients. (C) 2004 Elsevier Ireland Ltd. All rights reserved.