Cerebral uptake and elimination of desflurane, isoflurane, and halothane from rabbit brain: an in vivo NMR study.
Cerebral uptake and elimination of desflurane, isoflurane, and halothane from rabbit brain: an in vivo NMR study.
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兔脑中地氟烷、异氟烷和氟烷的脑吸收和消除：体内核磁共振研究。
DOI：
10.1097/00000542-199103000-00028
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发表时间：
1991
期刊：
影响因子：
8.8
通讯作者：
Eger2nd,EI
中科院分区：
文献类型：
--
作者：
Lockhart,SH;Cohen,Y;Yasuda,N;Freire,B;Taheri,S;Litt,L;Eger2nd,EI
作者使用活体19F核磁共振波谱测定了地氟烷、异氟烷和氟烷在兔脑中的摄取率和排除率。动物肌肉注射和静脉注射甲氧己胺并吸入70%一氧化二氮麻醉后，插入静脉和动脉导管，并进行气管切开和开颅手术。控制通气量以维持动脉二氧化碳分压(PaCO2)在35至45毫米汞柱之间。暴露一个直径2~2.5 cm的硬脑膜圆环，在其上放置一个0.9×1.0 cm的椭圆形表面线圈。脑麻醉剂浓度(CC)由4.7特斯拉光谱仪获得的光谱估算。用气相色谱测定吸入(FI)和呼气末(用药结束时表示为FA0)浓度来评估肺泡摄取和排出。在获得基线光谱后，给予挥发剂30分钟，然后120分钟消除。我们的发现表明，大脑的摄取和排出与溶解度相关：地氟烷的摄取和排出最快，异氟烷次之，氟烷最慢。在给药过程中，地氟醚的脑摄取(9min时CC/FI=0.690+/-0.049)大约是异氟醚(15min时CC/FI=0.691+/-0.020)的1.7倍，比氟烷(27min时CC/FI=0.662+/-0.040)快3倍。类似地氟烷的消除速度(9min时CC/Fa0=0.238+/-0.015)比异氟醚快1.7倍(15min时CC/Fa0=0.236+/-0.017)，比氟烷快3倍(27min时CC/Fa0=0.212+/-0.033)。
The authors used in vivo 19F nuclear magnetic resonance spectroscopy to determine rates of cerebral uptake and elimination of desflurane, isoflurane, and halothane in rabbits. After anesthetizing animals by intramuscular and intravenous injection of methohexital and inhalation of 70% nitrous oxide, intravenous and intraarterial catheters were inserted and a tracheostomy and craniotomy performed. Ventilation was controlled to maintain arterial carbon dioxide tension (PaCO2) from between 35 and 45 mmHg. A 2-2.5-cm diameter circle of dura was exposed, over which a 0.9 x 1.0-cm elliptical surface coil was placed. Cerebral anesthetic concentrations (CC) were estimated from spectra acquired on a 4.7-Tesla spectrometer. Alveolar uptake and elimination also were assessed, using inspired (FI) and end-tidal (denoted FA0 at the end of administration) concentrations measured by gas chromatography. After baseline spectra were obtained, volatile agents were administered for 30 min, followed by a 120-min period of elimination. Our findings demonstrate that cerebral uptake and elimination correlate with solubility: they are most rapid for desflurane, next most rapid for isoflurane, and least rapid for halothane. During administration, cerebral uptake of desflurane (CC/FI= 0.690+/-0.049 at 9 min) was approximately 1.7 times faster than isoflurane (CC/FI= 0.691+/-0.020 at 15 min) and 3 times faster than halothane (CC/FI= 0.662+/-0.040 at 27 min). Similarly, elimination rates for desflurane (CC/FA0= 0.238+/-0.015 at 9 min) were 1.7 times faster than isoflurane (CC/FA0= 0.236+/-0.017 at 15 min) and three times faster than halothane (CC/FA0= 0.212+/-0.033 at 27 min).(ABSTRACT TRUNCATED AT 250 WORDS)