Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000
Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000
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DOI：
10.1093/aje/kwi189
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发表时间：
2005-08-01
影响因子：
5
通讯作者：
Fixler, DE
中科院分区：
文献类型：
--
作者：
Gilboa, SM;Mendola, P;Fixler, DE
一项以人群为基础的病例对照研究调查了1997年至2000年间，在德克萨斯州7个县，孕妇在怀孕3-8周期间暴露于空气污染物、一氧化碳、二氧化氮、臭氧、二氧化硫和空气动力学直径< 10 μ m的颗粒物与某些心脏出生缺陷和活产唇腭裂的风险以及胎儿死亡之间的关系。对照的频率与病例的出生年份、生命状况和分娩时产妇居住的县相匹配。固定监测数据用于估计空气污染暴露。逻辑回归模型调整协变量可用在生命记录。当将暴露的最高四分位数与最低四分位数进行比较时，作者观察到一氧化碳与法洛四联症（比值比= 2.04,95%可信区间：1.26,3.29）、空气动力学直径< 10 μ m的颗粒物与孤立性房间隔缺损（比值比= 2.27,95%可信区间：1.43,3.60）、二氧化硫与孤立性室间隔缺损（比值比= 2.16,95%可信区间：1.51,3.09）呈正相关。一氧化碳与孤立性房间隔缺损、臭氧与孤立性室间隔缺损呈负相关。暴露于空气污染影响患唇裂风险的证据有限。暗示性的结果支持先前报道的臭氧暴露与肺动脉和瓣膜缺陷之间的联系。
A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter < 10 mu m in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. Controls were frequency matched to cases on year of birth, vital status, and maternal county of residence at delivery. Stationary monitoring data were used to estimate air pollution exposure. Logistic regression models adjusted for covariates available in the vital record. When the highest quartile of exposure was compared with the lowest, the authors observed positive associations between carbon monoxide and tetralogy of Fallot (odds ratio = 2.04, 95% confidence interval: 1.26, 3.29), particulate matter < 10 mu m in aerodynamic diameter and isolated atrial septal defects (odds ratio = 2.27, 95% confidence interval: 1.43, 3.60), and sulfur dioxide and isolated ventricular septal defects (odds ratio = 2.16, 95% confidence interval: 1.51, 3.09). There were inverse associations between carbon monoxide and isolated atrial septal defects and between ozone and isolated ventricular septal defects. Evidence that air pollution exposure influences the risk of oral clefts was limited. Suggestive results support a previously reported finding of an association between ozone exposure and pulmonary artery and valve defects.