Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy.
Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy.
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DOI：
10.2174/13894501113149990192
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发表时间：
2013-09
影响因子：
3.2
通讯作者：
Xie K
中科院分区：
文献类型：
--
作者：
Shi M;Cui J;Xie K
转录因子叉头盒蛋白M1（FOXM 1）在大多数癌症患者中过表达。这种过表达被认为在癌症的发病机制、进展和转移中起作用。FOXM 1的这种重要作用证明了其对癌症治疗的重要性。microRNA（miRNAs）是一类内源性的非编码单链小RNA，是转录后基因表达的重要调控因子。在肿瘤细胞中异常表达的miRNAs在肿瘤的发生和发展中具有重要作用。目前，miRNAs正被研究作为癌症的诊断和预后生物标志物和治疗工具。许多靶向miRNA及其相关通路的快速发现促进了基于miRNA的癌症治疗方法的发展。在这篇综述中，我们总结了FOXM 1和miRNA参与癌症发展的最新和最重要的发现，并描述了miRNA/FOXM 1信号通路在癌症发生和发展中的作用。通过调节miRNA表达靶向FOXM 1可能在癌症治疗中发挥作用，尽管miRNA递送方法仍然是建立这种新型疗法的关键挑战。
The transcription factor Forkhead box protein M1 (FOXM1) is overexpressed in the majority of cancer patients. This overexpression is implicated to play a role in the pathogenesis, progression, and metastasis of cancer. This important role of FOXM1 demonstrates} its significance to cancer therapy. MicroRNAs (miRNAs) are small noncoding, endogenous, single-stranded RNAs that are pivotal posttranscriptional gene expression regulators. MiRNAs aberrantly expressed in cancer cells have important roles in tumorigenesis and progression. Currently, miRNAs are being studied as diagnostic and prognostic biomarkers and therapeutic tools for cancer. The rapid discovery of many target miRNAs and their relevant pathways has contributed to the development of miRNA-based therapeutics for cancer. In this review, we summarize the latest and most significant findings on FOXM1 and miRNA involvement in cancer development and describe the role/roles of miRNA/FOXM1 signaling pathways in cancer initiation and progression. Targeting FOXM1 via regulation of miRNA expression may have a role in cancer treatment, although the miRNA delivery method remains the key challenge to the establishment of this novel therapy.
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