Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating
Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating
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DOI：
10.1016/j.jmb.2006.08.051
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发表时间：
2006-10-20
影响因子：
5.6
通讯作者：
Hirose, Sachiko
中科院分区：
文献类型：
--
作者：
Nakamura, Kazuhiro;Koyama, Yoshimasa;Hirose, Sachiko
感觉运动门控是一种专注于最显著刺激的功能，它的缺陷可能会导致认知完整性的崩溃，并可能反映出精神分裂症患者中感觉过载和认知碎片化带来的“泛滥”。感觉运动门控在婴儿期出现，在儿童时期成熟。支撑其发展的机制在很大程度上尚不清楚。在这里，我们筛选了小鼠的基因组，发现色氨酸羟化酶(TPH)与感觉运动门控的成熟有关。TPH是一种参与5-羟色胺生物合成的酶，它只在感觉运动门控成熟的断奶期间被证明是必需的，但对于它的出现是必不可少的。发育过程中适当的5-羟色胺水平是通过适当的肌动蛋白聚合形成感觉运动门控的成熟功能结构的基础。因此，在儿童时期保持适当的5-羟色胺水平可能对成年后成熟的感觉运动门控很重要。(C)2006爱思唯尔有限公司。保留所有权利。
Deficits in sensorimotor gating, a function to focus on the most salient stimulus, could lead to a breakdown of cognitive integrity, and could reflect the "flooding" by sensory overload and cognitive fragmentation seen in schizophrenia. Sensorimotor gating emerges at infancy, and matures during childhood. The mechanisms that underlie its development are largely unclear. Here, we screened the mouse genome, and found that tryptophan hydroxylase (TPH) is implicated in the maturation of sensorimotor gating. TPH, an enzyme involved in the biosynthesis of serotonin, proved to be required only during the weaning period for maturation of sensorimotor gating, but was dispensable for its emergence. Proper serotonin levels during development underlie the mature functional architecture for sensorimotor gating via appropriate actin polymerization. Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood. (c) 2006 Elsevier Ltd. All rights reserved.