Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration
Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration
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DOI：
10.1097/01.tp.0000231447.34240.3c
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发表时间：
2006-07-15
期刊：
影响因子：
6.2
通讯作者：
Reed, Elaine F.
中科院分区：
文献类型：
--
作者：
Jindra, Peter T.;Zhang, Xiaohai;Reed, Elaine F.
对移植器官表现出体液免疫反应的患者发生抗体介导的排斥反应和发生移植血管病变的风险增加。从历史上看，抗体被认为是通过补体介导的移植物内皮损伤引起移植排斥反应。最近，我们实验室和其他人的研究表明，内皮细胞表面1类分子的抗体连接可传导信号，导致功能改变，包括细胞存活蛋白的表达和细胞增殖。由抗体连接引发的细胞内事件依赖于分子聚集的程度，并受抗体浓度和人白细胞抗原（HLA）表达水平的影响。在这里，我们描述了我们最近发现的分子聚集对人类内皮细胞1类信号通路的影响。
Patients exhibiting a humoral immune response to the transplanted organ are at increased risk of antibody-mediated rejection and development of transplant vasculopathy. Historically, antibodies were thought to elicit transplant rejection through complement mediated damage of the endothelium of the graft. More recently, studies from our laboratory and others have shown that antibody ligation of class 1 molecules on the surface of endothelial cells transduces signals resulting in functional changes including expression of cell survival proteins and cell proliferation. The intracellular events initiated by antibody ligation are dependent upon the degree of molecular aggregation and influenced by the concentration of the antibody and level of human leukocyte antigen (HLA) expression. Herein we describe our recent findings on the effect of molecular aggregation on the class 1 signaling pathway in human endothelial cells.