Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans
Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans
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DOI：
10.1039/b504562b
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Willis, CL
中科院分区：
文献类型：
--
作者：
Barry, CS;Bushby, N;Willis, CL
用碳基亲核试剂捕获Prins环化反应途径的中间体，进一步深入了解了影响高烯丙醇与醛的酸介导反应的因素，从而能够设计有效的4-羟基-2，6-二取代四氢吡喃的合成。
Trapping intermediates on the Prins cyclisation pathway with carbon-based nucleophiles has given further insight into factors affecting the acid-mediated reactions of homoallylic alcohols with aldehydes, enabling the design of efficient syntheses of 4-hydroxy-2,6-disubstituted tetrahydropyrans.