Coupling the cell cycle to development and regeneration of the inner ear.
Coupling the cell cycle to development and regeneration of the inner ear.
复制标题
DOI：
10.1016/j.semcdb.2013.04.004
复制
发表时间：
2013-05
影响因子：
7.3
通讯作者：
T. Schimmang;U. Pirvola
中科院分区：
文献类型：
--
作者：
T. Schimmang;U. Pirvola
Cell cycle exit and acquirement of a postmitotic state is essential for the proper development of organs. In the present review, we examine the role of the cell cycle control in the sensory epithelia of the mammalian inner ear. We describe the roles of the core cell cycle regulators in the proliferation of prosensory cells and in the initiation and maintenance of terminal mitosis of the sensory epithelia. We also discuss how other intracellular signalling may influence the cell cycle. Finally, we address the question of whether manipulations of the cell cycle may have the potential to create replacement cells for the damaged inner sensory epithelia.
