Trends in Klebsiella pneumoniae carbapenemase-positive K. pneumoniae in US hospitals: report from the 2007-2009 SENTRY Antimicrobial Surveillance Program
Trends in Klebsiella pneumoniae carbapenemase-positive K. pneumoniae in US hospitals: report from the 2007-2009 SENTRY Antimicrobial Surveillance Program
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DOI：
10.1016/j.diagmicrobio.2013.03.032
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发表时间：
2013-07-01
影响因子：
2.9
通讯作者：
Lynfield, Ruth
中科院分区：
文献类型：
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作者：
Kaiser, Robyn M.;Castanheira, Mariana;Lynfield, Ruth
我们报告了2007-2009年通过SENTRY抗菌监测项目从美国医疗中心收集的临床分离株中碳青霉烯酶阳性肺炎克雷伯菌的流行情况（n = 42）。分离亚胺培南和美罗培南MIC >= 2 μ g/mL菌株，采用PCR方法筛选碳青霉烯酶基因。2049株肺炎克雷伯菌分离株中，126株（6.1%）对亚胺培南或美罗培南不敏感。113株（5.5%）分离出bla（KPC）。未发现其他碳青霉烯酶基因。就美国地区而言，2007年肺炎克雷伯菌碳青霉烯酶（KPC）阳性分离株的流行率为5.9%，2008年为4.9%，2009年为5.7%。比率最高的是中大西洋地区（总体为28.6%），随时间波动（2007-2009年分别为29%、23%和33%），其次是东北中部地区（总体为2.4%），有轻微上升趋势（2007-2009年为零，3.1%和3.8%）。根据更新的CLSI断点，所有kpc阳性生物都对碳青霉烯不敏感，尽管根据先前的断点，除了一个之外，所有生物都被相似地分类。(C) 2013爱思唯尔公司版权所有。
We report the prevalence of carbapenemase-positive Klebsiella pneumoniae among clinical isolates collected from us medical centers (n = 42) from 2007-2009 through the SENTRY Antimicrobial Surveillance Program. Isolates with imipenem or meropenem MIC >= 2 mu g/mL were screened by PCR for various carbapenemase genes. Of 2049 K. pneumoniae isolates, 126 (6.1%) were non-susceptible to imipenem or meropenem. bla(KPC) was identified in 113 isolates (5.5%). No other carbapenemase genes were identified. For US regions combined, prevalence of K. pneumoniae carbapenemase (KPC)-positive isolates were 5.9% in 2007, 4.9% in 2008, and 5.7% in 2009. Rates were highest in the Mid-Atlantic region (28.6% overall), with fluctuation over time (29%, 23%, and 33% from 2007-2009), followed by the East North Central region (2.4% overall), with a slightly increasing trend (nil, 3.1%, 3.8% from 2007-2009). All KPC-positive organisms were carbapenem non susceptible according to updated CLSI breakpoints, although all but one was similarly classified according to previous breakpoints. (C) 2013 Elsevier Inc. All rights reserved.