Genes and proteins of the transcriptional apparatus in mitochondria

Genes and proteins of the transcriptional apparatus in mitochondria
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线粒体转录装置的基因和蛋白质

DOI:
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发表时间:
1999
期刊:
影响因子:
--
通讯作者:
M. Gray
M. Gray
中科院分区:
--
文献类型:
--
作者:
T. Ikeda;M. Gray

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在这篇文章中,我们回顾了最近的进展,我们了解的生化和线粒体转录装置的进化,重点是开花植物(被子植物)。在迄今为止研究的大多数真核生物(包括植物)中,线粒体RNA(mtDNA)聚合酶是一种在细胞核中编码的单一多肽,噬菌体T3/T7样酶。虽然T3/T7 RNA聚合酶本身的进化起源仍然是一个谜,但噬菌体样mtDNA聚合酶的出现似乎与真核细胞内线粒体的出现密切相关。在被子植物中,几个研究小组已经发现了第二个噬菌样RNA聚合酶基因,显然是通过复制先前存在的编码线粒体RNA聚合酶的基因而产生的。除了叶绿体基因组编码的真细菌样RNA聚合酶外,第二个基因还指定了在叶绿体中起作用的噬菌体样活性。叶绿体的情况似乎重演了线粒体转录机制进化的早期阶段:也就是说,出现了一种噬菌体样酶,最终取代了最初在原线粒体基因组中编码的多亚基、真细菌样RNA聚合酶。在被子植物中,候选转录因子(启动子特异性DNA结合蛋白)的特点是在小麦(63 kDa)和豌豆(34和44 kDa)。单子叶植物和双子叶植物之间的这种差异可能反映了两个被子植物类群中mtDNA聚合酶识别的启动子序列的已知差异。
In this article we review recent advances in our understanding of the biochemistry and evolution of the mitochondrial transcriptional apparatus, with emphasis on flowering plants (angiosperms). In the majority of eukaryotes studied to date, including plants, the mitochondrial RNA (mtRNA) polymerase is a single-polypeptide, bacteriophage T3/T7-like enzyme, encoded in the nucleus. While the evolutionary origin of the T3/T7 RNA polymerase itself remains an enigma, the emergence of a phagelike mtRNA polymerase seems to have closely paralleled the appearance of mitochondria within the eukaryotic cell. In angiosperms, several groups have discovered a second phagelike RNA polymerase gene, evidently arising via duplication of a preexisting gene encoding the mtRNA polymerase. This second gene specifies a phagelike activity that functions in the chloroplast, in addition to the eubacteria-like RNA polymerase encoded by the chloroplast genome. The chloroplast situation appears to recapitulate an early stage in the evolution of the mitochondrial transcriptional machinery: that is, appearance of a phagelike enzyme that eventually displaced a multisubunit, eubacteria-like RNA polymerase originally encoded in the protomitochondrial genome. In angiosperms, candidate transcription factors (promoter-specific DNA-binding proteins) have been characterized in wheat (63 kDa) and pea (34 and 44 kDa). This difference between monocotyledonous and dicotyledonous plants may reflect known differences in the promoter sequences recognized by the mtRNA polymerase in the two angiosperm groups.
HMG1 样酵母线粒体组蛋白 HM 和细菌组蛋白样蛋白 HU 之间的功能互补。
DOI: --
发表时间: 1993
期刊: The Journal of biological chemistry
影响因子: --
作者:
Megraw,TL;Chae,CB
通讯作者: Chae,CB
DOI: 10.1093/nar/25.20.4055
发表时间: 1997-10-15
影响因子: 14.9
作者:
Caoile, AGFS;Stern, DB
通讯作者: Stern, DB
DOI: 10.1073/pnas.90.8.3147
发表时间: 1993-04-15
影响因子: 11.1
作者:
RASKIN, CA;DIAZ, GA;MCALLISTER, WT
通讯作者: MCALLISTER, WT
调节利什曼原虫线粒体中 tRNA 的输入。
DOI: 10.1016/s0167-4781(97)00197-8
发表时间: 1998
期刊: Biochimica et biophysica acta
影响因子: --
作者:
Suyama,Y;Wong,S;Campbell,DA
通讯作者: Campbell,DA
DOI: --
发表时间: 1986
期刊: The Journal of biological chemistry
影响因子: --
作者:
Bogenhagen,DF;Yoza,BK;Cairns,SS
通讯作者: Cairns,SS