Overview and findings from the rush Memory and Aging Project.
Overview and findings from the rush Memory and Aging Project.
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DOI：
10.2174/156720512801322663
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发表时间：
2012-07
影响因子：
2.1
通讯作者：
Wilson RS
中科院分区：
文献类型：
--
作者：
Bennett DA;Schneider JA;Buchman AS;Barnes LL;Boyle PA;Wilson RS
记忆与衰老项目是一项针对常见慢性衰老疾病的纵向、流行病学临床病理学队列研究，重点关注认知和运动功能的下降以及阿尔茨海默病 (AD) 的风险。在这篇手稿中，我们首先总结了研究设计和方法。然后，我们提供以下数据：1）运动功能与认知、残疾和死亡的关系； 2）危险因素与认知和运动结果、残疾和死亡的关系； 3）神经病理学指标与认知结果的关系； 4）危险因素与神经病理指标的关系； 5) 其他研究结果。对调查结果进行了讨论并结合实际情况进行讨论。
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: 1) the relation of motor function to cognition, disability, and death; 2) the relation of risk factors to cognitive and motor outcomes, disability and death; 3) the relation of neuropathologic indices to cognitive outcomes; 4) the relation of risk factors to neuropathologic indices; and 5) additional study findings. The findings are discussed and contextualized.