Distinct genomic architecture of Plasmodium falciparum populations from South Asia
Distinct genomic architecture of Plasmodium falciparum populations from South Asia
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DOI：
10.1016/j.molbiopara.2016.07.005
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发表时间：
2016-11-01
影响因子：
1.5
通讯作者：
Rathod, Pradipsinh K.
中科院分区：
文献类型：
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作者：
Kumar, Shiva;Mudeppa, Devaraja G.;Rathod, Pradipsinh K.
之前对恶性疟原虫种群的全基因组比较没有包括从印度次大陆收集的样本，尽管印度每年有200万人感染疟疾，大约5万人死于这种疾病。全球寄生虫的分层揭示了不同大陆寄生虫基因型的空间相关性。在这里，通过从距离计算中去除var基因和基因间区域，进一步改进了基因组分析以获得国家级分辨率。发现来自印度的恶性疟原虫基因组之间的亲缘关系最为密切。他们最近的邻居是孟加拉国和缅甸，其次是泰国。来自东南亚、非洲和南美洲其他地区的样本距离越来越远，显示出高分辨率的基因组-地理连续体。这种基因组分层方法将有助于监测南亚地区疟疾寄生虫的变异，以及可能由国内和跨境迁徙引起的寄生虫种群的未来变化。(C) 2016作者。Elsevier B.V.出版
Previous whole genome comparisons of Plasmodium falciparum populations have not included collections from the Indian subcontinent, even though two million Indians contract malaria and about 50,000 die from the disease every year. Stratification of global parasites has revealed spatial relatedness of parasite genotypes on different continents. Here, genomic analysis was further improved to obtain country-level resolution by removing var genes and intergenic regions from distance calculations. P. falciparum genomes from India were found to be most closely related to each other. Their nearest neighbors were from Bangladesh and Myanmar, followed by Thailand. Samples from the rest of Southeast Asia, Africa and South America were increasingly more distant, demonstrating a high-resolution genomic-geographic continuum. Such genome stratification approaches will help monitor variations of malaria parasites within South Asia and future changes in parasite populations that may arise from in-country and cross-border migrations. (C) 2016 The Author(s). Published by Elsevier B.V.