Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women
Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women
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DOI：
10.1136/ard.2007.072736
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发表时间：
2008-04-01
影响因子：
27.4
通讯作者：
Benito-Garcia, E.
中科院分区：
文献类型：
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作者：
Costenbader, K. H.;Feskanich, D.;Benito-Garcia, E.
目的：维生素 D 具有免疫调节作用，可预防系统性红斑狼疮 (SLE) 和类风湿性关节炎 (RA) 的发展。方法：我们在护士健康研究和护士健康研究 II 队列中，从 1980 年至 2002 年跟踪的 186 389 名女性中发现了 SLE 和 RA 的发病病例。我们排除了病历审查未证实患有 SLE 或 RA 的受试者以及未能返回调查问卷的受试者。半定量食物频率调查问卷评估了食物和补充剂中维生素 D 的摄入量。我们在每个两年周期中使用累积更新的总能量调整饮食暴露量。在年龄调整和 Cox 比例风险模型中检查了维生素 D 摄入量与 SLE 和 RA 事件之间的关系，并针对混杂因素进行了调整。使用荟萃分析随机效应模型汇总结果。结果：我们通过饮食信息确认了 190 例 SLE 病例和 722 例 RA 病例。维生素 D 摄入量的增加与发生 SLE 或 RA 的相对风险无关。结论：在这些大型前瞻性女性队列中，维生素 D 摄入量与 SLE 或 RA 风险无关。
Objectives: Vitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Methods: We identified incident cases of SLE and RA among 186 389 women followed from 1980 to 2002 in the Nurses' Health Study and Nurses' Health Study II cohorts. We excluded subjects where SLE or RA was not confirmed by medical record review, and those who failed to return questionnaires. Semi-quantitative food frequency questionnaires assessed vitamin D intake from food and supplements. We used cumulative-updated total energy-adjusted dietary exposures for each 2-year cycle. Relationships between vitamin D intake and incident SLE and RA were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results were pooled using meta-analysis random effects models.Results: We confirmed 190 incident cases of SLE and 722 of RA with dietary information. Increasing levels of vitamin D intake had no relationship to the relative risk of developing either SLE or RA.Conclusions: Vitamin D intake was not associated with risk of SLE or RA in these large prospective cohorts of women.