SUBFORNICAL ORGAN EFFERENTS INFLUENCE THE EXCITABILITY OF NEUROHYPOPHYSEAL AND TUBEROINFUNDIBULAR PARAVENTRICULAR NUCLEUS NEURONS IN THE RAT
SUBFORNICAL ORGAN EFFERENTS INFLUENCE THE EXCITABILITY OF NEUROHYPOPHYSEAL AND TUBEROINFUNDIBULAR PARAVENTRICULAR NUCLEUS NEURONS IN THE RAT
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DOI：
10.1159/000124015
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发表时间：
1984-01-01
影响因子：
4.1
通讯作者：
RENAUD, LP
中科院分区：
文献类型：
--
作者：
FERGUSON, AV;DAY, TA;RENAUD, LP
电刺激穹窿下器（SFO）改变室旁核神经元的兴奋性。细胞外记录表明，单一刺激传递到SFO对神经垂体催产素和血管加压素含有神经元的主导作用是兴奋性的增加。在测试的35%的细胞中，这种兴奋表现出长的潜伏期（44.3 ± 0.5）。3.4 ms）持续时间延长（208.7 ±. 23.5 ms），而在16%的神经元中，观察到的兴奋可被描述为短潜伏期（24.7 ± 0.00ms）。1.8 ms）短持续时间（11.6 ±. 1.4 ms）。其余的细胞逆向确定为投射到垂体后叶，12%的SFO刺激后表现出初始的兴奋性下降，而其余的37%不受影响。提出的证据表明，在SFO区域中的刺激导致短的潜伏期（27.9 . ±. 2.4 ms）短持续时间（7.8 ±. 0.7 ms）的兴奋性增加，在22%的逆向识别PVN结节漏斗神经元测试。电生理证据支持拟议的作用，穹窿下器官的控制垂体后叶和前叶功能。
Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopression containing neurons is an increase in excitability. In 35% of cells tested, this excitation showed a long latency (44.3 .+-. 3.4 ms) prolonged duration (208.7 .+-. 23.5 ms), while in 16% of the neurons the excitation observed may be described as short latency (24.7 .+-. 1.8 ms) short duration (11.6 .+-. 1.4 ms). Of the remaining cells antidromically identified as projecting to the posterior pituitary, 12% showed initial decreases in excitability following SFO stimulation while the remaining 37% were unaffected. Evidence is presented demonstrating that stimulation in the region of the SFO results in short latency (27.9 .+-. 2.4 ms) short duration (7.8 .+-. 0.7 ms) increases in excitability in 22% of antidromically identified PVN tuberoinfundibular neurons tested. Electrophysiological evidence in support of the proposed role of the subfornical organ in the control of posterior and anterior pituitary function is presented.