Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via Δ2-thiazolines
Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via Δ2-thiazolines
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DOI：
10.1023/b:modi.0000006800.46154.99
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发表时间：
2003-06-01
影响因子：
3.8
通讯作者：
Almqvist, Fredrik
中科院分区：
文献类型：
--
作者：
Emtenas, Hans;Taflin, Camilla;Almqvist, Fredrik
报道了一种新的微波辐射合成光学活性双环2-吡啶二酮的方法。该合成是通过Delta（2）-噻唑啉的两步程序，与使用常规加热时的2天相比，其仅需要3 ± 2分钟的反应时间。优化的条件被证明是适合于合成一个小的图书馆在优异的产率和有限的外消旋。
A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via Delta(2)-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.