The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance
The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance
复制标题
卵巢癌干细胞和小生境的标志：探索它们在治疗抵抗中的和谐相互作用
DOI：
10.1016/j.semcancer.2021.03.038
复制
发表时间：
2021-12-04
影响因子：
14.5
通讯作者：
Katabuchi, Hidetaka
中科院分区：
文献类型：
--
作者：
Motohara, Takeshi;Yoshida, Go J.;Katabuchi, Hidetaka
“癌症干细胞”的概念在过去几十年中不断发展，癌症干细胞生物学研究已进入显著进展阶段。肿瘤干细胞是一个主要的决定因素，有助于建立表型和功能的肿瘤内异质性与其周围的“癌症干细胞龛”同步。“它们是各种类型恶性肿瘤中癌症发生、转移和治疗耐药性的驱动力。事实上，卵巢癌干细胞及其微环境之间的相互作用涉及腹膜内环境中复杂但巧妙协调的肿瘤微环境，特别是导致晚期卵巢癌患者的化疗耐药性。在此，我们回顾了我们目前对卵巢癌干细胞生物学特征的理解的原则，主要集中在获得性化疗耐药的确切机制上。此外，我们强调了各种癌症相关的基质细胞和免疫细胞在创造可能的癌症干细胞小生境中的特定作用，这些小生境调节卵巢癌的干细胞性。
The concept of a "cancer stem cell" has evolved over the past decades, and research on cancer stem cell biology has entered into a stage of remarkable progress. Cancer stem cells are a major determining factor contributing to the establishment of phenotypic and functional intratumoral heterogeneity in synchronization with their surrounding "cancer stem cell niches." They serve as the driving force for cancer initiation, metastasis, and therapeutic resistance in various types of malignancies. In verity, reciprocal interplay between ovarian cancer stem cells and their niches involves a complex but ingeniously orchestrated tumor microenvironment within the intraperitoneal milieu and especially contribute to chemotherapy resistance in patients with advanced ovarian cancer. Herein, we review the principles of our current understanding of the biological features of ovarian cancer stem cells, focusing mainly on the precise mechanisms underlying acquired chemotherapy resistance. Furthermore, we highlight the specific roles of various cancer-associated stromal and immune cells in creating possible cancer stem cell niches that regulate ovarian cancer stemness.