Gene-environment interactions in vulnerability to cocaine intravenous self-administration: a brief social experience affects intake in DBA/2J but not in C57BL/6J mice
Gene-environment interactions in vulnerability to cocaine intravenous self-administration: a brief social experience affects intake in DBA/2J but not in C57BL/6J mice
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DOI：
10.1007/s00213-007-0777-0
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发表时间：
2007-08-01
影响因子：
3.4
通讯作者：
Deroche-Gamonet, Veronique
中科院分区：
文献类型：
--
作者：
van der Veen, Rixt;Piazza, Pier Vincenzo;Deroche-Gamonet, Veronique
可卡因服用行为和滥用倾向的个体差异是清楚观察到的，但对潜在的机制仍然知之甚少。基因-环境相互作用的作用已被提出，但仍然hypothetic.Objectives我们研究基因-环境相互作用是否影响小鼠静脉内可卡因自我管理（SA）。我们测试了过去短暂的群体饲养经历对两种近交系小鼠C57 BL/6 J（C57）和DBA/2 J（DBA）中可卡因SA的影响。方法成年C57和DBA小鼠在抵达实验室后单独饲养。3周后，将每种品系的一半动物分组饲养19天。一周后结束组住房，可卡因SA或测量大脑可卡因水平happened.Results单独和前组圈养的C57小鼠没有不同的可卡因SA。相反，与单独饲养的DBA相比，前组饲养的DBA小鼠显示出剂量-反应曲线的上移。大脑可卡因水平的差异不能解释所观察到的行为differentiation.Conclusions这些结果表明，可卡因增强效应的脆弱性可以受到基因-环境相互作用。我们提出了一个小鼠模型的特点基因-环境相互作用的脆弱性可卡因服用行为。
Rationale Individual differences in cocaine-taking behavior and liability to develop abuse are clearly observed, but underlying mechanisms are still poorly understood. A role for gene-environment interactions has been proposed but remains hypothetical.Objectives We investigated whether gene-environment interactions influence intravenous cocaine self-administration (SA) in mice. We tested the effect of a past short group housing experience on cocaine SA in two inbred strains of mice, the C57BL/6J (C57) and DBA/2J (DBA).Methods Adult C57 and DBA mice were individually housed upon arrival in the laboratory. After 3 weeks, half of the animals of each strain were group housed for 19 days. One week after the end of group housing, cocaine SA or measurement of brain cocaine levels took place.Results Individually and ex-group-housed C57 mice did not differ for cocaine SA. On the contrary, the ex-group-housed DBA mice showed an upward shift in the dose-response curve as compared to individually housed DBA. Differences in brain cocaine levels could not account for the observed behavioral differences.Conclusions These results demonstrate that vulnerability to cocaine reinforcing effects can be affected by gene-environment interactions. We propose a mouse model for the characterization of gene-environment interactions in the vulnerability to cocaine-taking behavior.