Regulatory role of SGT1 in early R gene-mediated plant defenses
Regulatory role of SGT1 in early R gene-mediated plant defenses
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DOI：
10.1126/science.1067747
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发表时间：
2002-03-15
期刊：
影响因子：
56.9
通讯作者：
Parker, JE
中科院分区：
文献类型：
--
作者：
Austin, MJ;Muskett, P;Parker, JE
动物SGT1是Skp1-Cullin-F-box蛋白（SCF）泛素连接酶的一个组成部分，靶向调节蛋白降解。两个高度同源的拟南芥SGT1基因中的一个（SGT1b）突变使多个抗性(R)基因赋予的早期植物防御功能失效。SGT1a不能补偿SGT1b在电阻中的功能损失。R基因对SGT1b和第二个抗性信号基因RAR1的需求不同，RAR1先前被认为是SGT1相互作用因子。此外，SGT1b和RAR1还参与了rpp5介导的病原体识别。这些数据表明，SGT1和RAR1在植物抗病过程中既有不同的功能，也有协同的功能。
Animal SGT1 is a component of Skp1-Cullin-F-box protein (SCF) ubiquitin ligases that target regulatory proteins for degradation. Mutations in one (SGT1b) of two highly homologous Arabidopsis SGT1 genes disable early plant defenses conferred by multiple resistance (R) genes. Loss of SGT1b function in resistance is not compensated for by SGT1a. R genes differ in their requirements for SGT1b and a second resistance signaling gene, RAR1, that was previously implicated as an SGT1 interactor. Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition. These data imply both operationally distinct and cooperative functions of SGT1 and RAR1 in plant disease resistance.