Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrome
Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrome
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DOI：
10.1016/j.diabres.2007.09.004
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发表时间：
2008-02-01
影响因子：
5.1
通讯作者：
Harada, Mine
中科院分区：
文献类型：
--
作者：
Nakamura, Hirofumi;Ito, Hiroyuki;Harada, Mine
背景：代谢综合征（MetS）是已知的心血管疾病的风险增加。据报道，MetS受试者的C反应蛋白（CRP）升高。然而，MetS的组成部分主要是海拔elevation.Methods：我们研究了628显然健康的日本受试者（男性262，女性366，年龄19 - 85岁）。测量体重指数、腰围、血压、血脂、血糖、胰岛素和C反应蛋白。结果：偏相关分析显示，在与代谢综合征相关的变量中，WC与CRP的相关性最强。CRP随着MetS组分数量的增加而增加。经人口统计学变量校正后，MetS受试者的平均CRP值高于无MetS受试者，进一步校正MetS相关变量后显示，仅当进一步校正WC时，两组之间的显著差异才消失。多元线性回归分析中，对CRP水平解释最强的自变量是WC，其次是HDL-胆固醇。最后，比较按腹部肥胖和MetS成分数量分层的各组的CRP水平，发现与无腹部肥胖的受试者相比，无论除WC之外的MetS成分数量如何，患有腹部肥胖的受试者往往表现出更高的CRP水平。结论：MetS受试者表现出更高的CRP水平，而CRP升高的主要决定因素是WC。(c)2007年由Elsevier爱尔兰有限公司出版。
Background: Metabolic syndrome (MetS) is known to increase the risk of cardiovascular disease. C-reactive protein (CRP) has been reported to be elevated in subjects with MetS. However, which component of MetS contributes mostly to the elevation has not been studied in detail.Methods: We studied 628 apparently healthy Japanese subjects (men 262, women 366, age 19-85 years). Body mass index, waist circumference (WC), blood pressure, lipids, glucose, insulin and CRP were measured. MetS was defined according to the National Cholesterol Education Program's Adult Treatment Panel III report.Results: In partial correlation analysis, WC showed the strongest correlation with CRP among the variables related to MetS. CRP increased as the number of MetS components increased. The mean CRP value adjusted for demographic variables was higher in subjects with MetS than those without MetS, and further adjustments with variables related to MetS revealed that the significant difference between the two groups disappeared only when further adjustment was made for WC. In multiple linear regression analysis, the independent variable that most strongly explained the CRP level was WC, which was followed by HDL-cholesterol. Finally, comparison of the CRP levels in groups stratified by abdominal obesity and the number of MetS components revealed that those with abdominal obesity tended to show higher CRP levels compared with those without abdominal obesity regardless of the number of MetS components other than WC.Conclusions: Subjects with MetS showed higher levels of CRP and the main determinant of the CRP elevation was WC. (c) 2007 Published by Elsevier Ireland Ltd.