SCANNING ELECTRON-MICROSCOPY OF INDUCED CELL ROUNDING OF MOUSE ADRENAL-CORTEX TUMOR-CELLS IN CULTURE
SCANNING ELECTRON-MICROSCOPY OF INDUCED CELL ROUNDING OF MOUSE ADRENAL-CORTEX TUMOR-CELLS IN CULTURE
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DOI：
10.1016/0040-8166(77)90034-9
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发表时间：
1977-01-01
期刊：
影响因子：
2.6
通讯作者：
BAYER, RC
中科院分区：
文献类型：
--
作者：
CUPRAK, LJ;LAMMI, CJ;BAYER, RC
The surface topology of mouse adrenal cortex tumor cells of primary or clonal origin grown as monolayer cultures was observed by scanning electron microscopy following exposure to substances that effect steroid release and/or cell rounding. ACTH induced cell rounding with a concomitant profuse development of fine microvilli in a nonsynchronously dividing cell population. This was less pronounced with other steroidogenic substances and absent in EGTA [ethylene glycol-bis(aminoethylether)-N,N''-tetraacetic acid] or trypsin-treated cells. Morphological alterations occurred most rapidly with c[cyclic]AMP and least rapidly with db[dibutyryl]cAMP. The rapid development of fine microvilli with ACTH is proposed as a specific hormone mediated response.
