Esophageal neuroendocrine carcinoma complicated with unexpected hyperprocalcitonin: Case report and literature review.
Esophageal neuroendocrine carcinoma complicated with unexpected hyperprocalcitonin: Case report and literature review.
复制标题
食管神经内分泌癌并发降钙素原异常升高病例报告及文献复习
DOI：
10.1097/md.0000000000012219
复制
发表时间：
2018-10
期刊：
影响因子：
1.6
通讯作者：
Liang T
中科院分区：
文献类型：
--
作者：
Hu Q;Jin P;Zhao X;Wu W;Huang B;Shao S;Que R;Liang T
神经内分泌肿瘤伴有高降钙素原是相对罕见的，发病率低。一个63岁的发烧男性持续腰痛意外地提出了一个极端高降钙素原。影像学检查显示食管壁增厚伴椎体骨破坏和肝脏病变。内窥镜检查发现不规则形状的食管病变，证实为低分化NETs。伴有多发性转移的食管NETs。患者接受化疗，并在随访期间通过降钙素原水平和放射学评估。在治疗过程中，降钙素原水平随治疗反应和疾病进展而改变。降钙素原升高发生在一些有神经内分泌成分的恶性肿瘤中，如消化系统的NETs。
Neuroendocrine tumors (NETs) with hyperprocalcitonin are relatively rare with a low incidence rate. An afebrile 63-year-old male with persistent low back pain unexpectedly presented with an extreme hyperprocalcitonin. Radiological assessment revealed thickening of the esophageal wall with vertebral bone destruction and liver lesions. Endoscopy showed an irregular-shaped esophageal lesion which turned out to be poorly-differentiated NETs. Esophageal NETs with multiple metastases. The patient was treated with chemotherapies, and was evaluated by procalcitonin level and radiology within follow-up. The procalcitonin levels were altered in line with the therapeutic response and disease progression during the treatment course. Increased procalcitonin occurs in several malignancies with neuroendocrine components, such as NETs of the digestive system.