Chronic thromboembolic pulmonary hypertension.
Chronic thromboembolic pulmonary hypertension.
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DOI：
10.1007/s12471-014-0592-2
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Post MC
中科院分区：
文献类型：
--
作者：
Schölzel BE;Snijder RJ;Mager JJ;van Es HW;Plokker HW;Reesink HJ;Morshuis WJ;Post MC
慢性肺血栓栓塞性疾病是严重肺动脉高压的重要原因，因此与显著的发病率和死亡率相关。这种情况的预后反映了相关的右心室功能障碍的程度，可预测的死亡率与潜在的肺动脉高压的严重程度有关。如果不治疗，预后很差。肺动脉内膜切除术是缓解慢性血栓栓塞性肺动脉高压患者肺动脉阻塞的首选治疗方法，并且取得了显着成功。外科技术的进步沿着肺动脉高压特异性药物的引入，为大多数患有该疾病的患者提供了治疗选择。然而，由于远端肺血管阻塞或严重的合并症，大量患者不适合进行肺动脉内膜切除术。因此，在专家中心仔细选择手术候选人至关重要。本文综述了慢性血栓栓塞性肺动脉高压的诊断方法以及现有的外科和内科治疗方法。本文的在线版本（doi：10.1007/s12471-014-0592-2）包含补充材料，可供授权用户使用。
Chronic pulmonary thromboembolic disease is an important cause of severe pulmonary hypertension, and as such is associated with significant morbidity and mortality. The prognosis of this condition reflects the degree of associated right ventricular dysfunction, with predictable mortality related to the severity of the underlying pulmonary hypertension. Left untreated, the prognosis is poor. Pulmonary endarterectomy is the treatment of choice to relieve pulmonary artery obstruction in patients with chronic thromboembolic pulmonary hypertension and has been remarkably successful. Advances in surgical techniques along with the introduction of pulmonary hypertension-specific medication provide therapeutic options for the majority of patients afflicted with the disease. However, a substantial number of patients are not candidates for pulmonary endarterectomy due to either distal pulmonary vascular obstruction or significant comorbidities. Therefore, careful selection of surgical candidates in expert centres is paramount. The current review focuses on the diagnostic approach to chronic thromboembolic pulmonary hypertension and the available surgical and medical therapeutic options. The online version of this article (doi:10.1007/s12471-014-0592-2) contains supplementary material, which is available to authorized users.
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作者：
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DOI：
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