The role of primary lymph node sites in survival and mortality prediction in Hodgkin lymphoma: a SEER population-based retrospective study.
The role of primary lymph node sites in survival and mortality prediction in Hodgkin lymphoma: a SEER population-based retrospective study.
复制标题
DOI：
10.1002/cam4.1280
复制
发表时间：
2018-04
期刊：
影响因子：
4
通讯作者：
Huy NT
中科院分区：
文献类型：
--
作者：
Ebied A;Thanh Huan V;Makram OM;Sang TK;Ghorab M;Ngo HT;Iraqi A;Kamel MG;Dang TN;Vuong NL;Hirayama K;Huy NT
随着霍奇金淋巴瘤（HL）的诊断和治疗方式不断改进，影响生存的患者相关因素变得更加难以识别。关于淋巴结 (LN) 受累的原发部位与 HL 患者生存之间的关系知之甚少。我们使用生存分析和时间间隔多元逻辑回归 (MLR) 回顾性分析了美国监测、流行病学和最终结果 (SEER) 数据库，其中包含 1973 年至 2010 年间报告的 12,658 名 HL 患者，以揭示这种关系。所有原发淋巴结部位对 HL 患者生存的影响均得到支持。腹内（IAB）原发淋巴结部位与最差生存率显着相关。盆腔 (P) LN 部位与 1 年总死亡率 (OM) 和 1 年癌症特异性死亡率 (CSM) 的概率分别为近 2 倍和 2.5 倍，显着且独立相关。头面颈 (HFN) 原发淋巴结部位是更好的整体生存率和 HL 特异性生存率的重要且独立的预测因素。腹内原发淋巴结部位的生存率较差可能与年龄较大或 HL 晚期有关。腹腔内和盆腔淋巴结部位的侵袭性背后的生物学基础仍有待研究。
As diagnostic and therapeutic modalities for Hodgkin's Lymphoma (HL) continue to improve, patient‐related factors affecting survival become more difficult to identify. Very little is known about the relationship between the primary site of lymph node (LN) involvement and survival of HL patients. We retrospectively analyzed the United States Surveillance, Epidemiology and End Results (SEER) database for 12,658 HL patients reported between 1973 and 2010 using survival analysis and time‐interval multiple logistic regression (MLR) to disclose that relationship. The effect of all primary LN sites on the survival of HL patients was supported. The intra‐abdominal (IAB) primary LN site was significantly associated with the worst survival. The pelvic (P) LN sites were significantly and independently associated with nearly 2 times and 2.5 times the probability of having 1‐year overall mortality (OM) and 1‐year cancer‐specific mortality (CSM), respectively. Head, face and neck (HFN) primary LN sites were significant and independent predictors of better overall and HL‐specific survival. A worse survival with the intra‐abdominal primary LN site was probably related to their association with higher age, or advanced stages of HL. The biological basis behind the aggressiveness of intra‐abdominal and pelvic LN sites is yet to be investigated.
登录
查看更多内容
影响因子：
45.3
作者：
Diehl, V;Sextro, M;Stein, H
通讯作者：
Stein, H
影响因子：
3.1
作者：
Glimelius, I;Molin, D;Enblad, G
通讯作者：
Enblad, G
DOI：
10.1182/asheducation-2006.1.266
发表时间：
2006-01-01
期刊：
Hematology. American Society of Hematology. Education Program
影响因子：
--
作者：
Nogova, Lucia;Rudiger, Thomas;Engert, Andreas
通讯作者：
Engert, Andreas
影响因子：
2.6
作者：
Darabi, K;Sieber, M;Diehl, V
通讯作者：
Diehl, V
影响因子：
45.3
作者：
Cheson, Bruce D.;Fisher, Richard I.;Lister, T. Andrew
通讯作者：
Lister, T. Andrew