Paracardial fat and vitamin A: a mechanism for regulating exercise performance.
Paracardial fat and vitamin A: a mechanism for regulating exercise performance.
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心旁脂肪和维生素 A：调节运动表现的机制。
DOI：
10.1172/jci145969
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Morrow,JohnP
中科院分区：
文献类型：
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作者：
Joseph,LeroyC;Morrow,JohnP
不同的脂肪库具有不同的生理功能。在本期JCI上发表的一项挑衅性研究中，Petrosino等人。研究心脏旁脂肪在全身代谢和运动生理学中的作用。Petrosino等人。研究表明，来自老年小鼠或喂食西方饮食的小鼠的心脏旁脂肪样本降低了酒精脱氢酶1(ADH1)的水平。来自肥胖患者的心脏旁脂肪样本也降低了ADH1mRNA的水平，这支持了翻译相关性。Adh1-KO小鼠的额外实验和外科脂肪移植实验提供了额外的机制洞察力。心脏旁脂肪可能通过改变循环代谢物和/或内分泌效应来调节运动能力。ADH1似乎调节心旁脂肪的线粒体含量，这是一种由视黄醛介导的机制。当ADH1激活时，心旁脂肪具有棕色脂肪的特征，这有利于运动表现。有必要进行进一步的研究，以确定这些发现的转化潜力，例如，在心内直视手术时去除心脏旁脂肪是否可以通过增加运动能力来缩短恢复时间。
Different fat depots have different physiologic functions. In a provocative study published in this issue of theJCI, Petrosino et al. investigate the role of paracardial fat in whole-body metabolism and exercise physiology. Petrosino et al. show that paracardial fat samples from older mice or mice fed a Western diet had decreased levels of alcohol dehydrogenase 1 (ADH1). Paracardial fat samples from humans with obesity also had decreased levels ofADH1mRNA, supporting the translational relevance. Additional experiments withAdh1-KO mice and surgical fat transplantation experiments provide additional mechanistic insight. Paracardial fat may regulate exercise performance by altering circulating metabolites and/or endocrine effects. ADH1 appears to regulate the mitochondrial content of paracardial fat, a mechanism mediated by retinaldehyde. When ADH1 is active, the paracardial fat has characteristics of brown fat, which is beneficial for exercise performance. Further research is warranted to determine the translational potential of these findings, such as whether removing paracardial fat at the time of open-heart surgery might improve recovery time by increasing exercise capacity.