EXPRESSION OF THE GENE FOR THE NEURONAL INTERMEDIATE FILAMENT PROTEIN ALPHA-INTERNEXIN COINCIDES WITH THE ONSET OF NEURONAL DIFFERENTIATION IN THE DEVELOPING RAT NERVOUS-SYSTEM
EXPRESSION OF THE GENE FOR THE NEURONAL INTERMEDIATE FILAMENT PROTEIN ALPHA-INTERNEXIN COINCIDES WITH THE ONSET OF NEURONAL DIFFERENTIATION IN THE DEVELOPING RAT NERVOUS-SYSTEM
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DOI：
10.1002/cne.903420202
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发表时间：
1994-04-08
影响因子：
2.5
通讯作者：
LIEM, RKH
中科院分区：
文献类型：
--
作者：
FLIEGNER, KH;KAPLAN, MP;LIEM, RKH
虽然神经丝一直被认为是神经元分化的早期标志，但在发育中的中枢神经系统(CNS)的大多数新生的有丝分裂后神经元中都不能检测到它们。在这里，我们发现这些神经元已经高水平表达神经元中间丝蛋白α-Interexin。Alpha-interexin在大多数(如果不是全部)神经元开始分化时表达，并且与波形蛋白没有重叠，波形蛋白在中枢神经系统中的表达仅限于有丝分裂神经元前体。在成人中，α-Interexin是小脑颗粒细胞表达的唯一中间丝基因，小脑颗粒细胞是细口径平行纤维的来源；相反，神经丝蛋白在大神经元中高表达，而大神经元低水平表达α-Interexin。这些数据表明，神经元中间丝可能不仅通过改变它们的数量，而且通过改变它们的亚单位组成来调节轴突的稳定性和/或直径。(C)1994年Wiley-Liss，Inc.
While neurofilaments have long been considered early markers of neuronal differentiation, they cannot be detected in most newly postmitotic neurons of the developing central nervous system (CNS). Here we show that these neurons already express the neuronal intermediate filament protein alpha-internexin at high levels. alpha-internexin is expressed by most, if not all, neurons as they begin differentiation and shows no overlap with vimentin, whose expression in the CNS is restricted to mitotic neuronal precursors. In the adult, alpha-internexin is the only intermediate filament gene expressed by the cerebellar granule cells, the source of the thin-caliber parallel fibers; conversely, neurofilament proteins are highly expressed in large neurons, which express alpha-internexin at low levels. These data suggest that neuronal intermediate filaments may regulate axonal stability and/or diameter through changes not only in their number, but also in their subunit composition. (C) 1994 Wiley-Liss, Inc.